Sonoclot(®)-based method to detect iron enhanced coagulation

Vance G. Nielsen, Jon Henderson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Volume42
Issue number1
DOIs
StatePublished - Jul 1 2016

Keywords

  • Carbon monoxide
  • Hypercoagulability
  • Iron
  • Viscoelasticity
  • Viscosity

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

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