Sonoclot(®)-based method to detect iron enhanced coagulation

Vance G. Nielsen, Jon Henderson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Volume42
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Iron
Thrombophilia
Carbon Monoxide
Heme Oxygenase (Decyclizing)
Sickle Cell Anemia
Renal Dialysis

Keywords

  • Carbon monoxide
  • Hypercoagulability
  • Iron
  • Viscoelasticity
  • Viscosity

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Sonoclot(®)-based method to detect iron enhanced coagulation. / Nielsen, Vance G.; Henderson, Jon.

In: Journal of Thrombosis and Thrombolysis, Vol. 42, No. 1, 01.07.2016, p. 1-5.

Research output: Contribution to journalArticle

@article{76b3d26204df491c82429a528cb71d1f,
title = "Sonoclot({\circledR})-based method to detect iron enhanced coagulation",
abstract = "Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.",
keywords = "Carbon monoxide, Hypercoagulability, Iron, Viscoelasticity, Viscosity",
author = "Nielsen, {Vance G.} and Jon Henderson",
year = "2016",
month = "7",
day = "1",
doi = "10.1007/s11239-015-1293-4",
language = "English (US)",
volume = "42",
pages = "1--5",
journal = "Journal of Thrombosis and Thrombolysis",
issn = "0929-5305",
publisher = "Springer Netherlands",
number = "1",

}

TY - JOUR

T1 - Sonoclot(®)-based method to detect iron enhanced coagulation

AU - Nielsen, Vance G.

AU - Henderson, Jon

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.

AB - Thrombelastographic methods have been recently introduced to detect iron mediated hypercoagulability in settings such as sickle cell disease, hemodialysis, mechanical circulatory support, and neuroinflammation. However, these inflammatory situations may have heme oxygenase-derived, coexistent carbon monoxide present, which also enhances coagulation as assessed by the same thrombelastographic variables that are affected by iron. This brief report presents a novel, Sonoclot-based method to detect iron enhanced coagulation that is independent of carbon monoxide influence. Future investigation will be required to assess the sensitivity of this new method to detect iron mediated hypercoagulability in clinical settings compared to results obtained with thrombelastographic techniques.

KW - Carbon monoxide

KW - Hypercoagulability

KW - Iron

KW - Viscoelasticity

KW - Viscosity

UR - http://www.scopus.com/inward/record.url?scp=85017073214&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017073214&partnerID=8YFLogxK

U2 - 10.1007/s11239-015-1293-4

DO - 10.1007/s11239-015-1293-4

M3 - Article

C2 - 26497986

VL - 42

SP - 1

EP - 5

JO - Journal of Thrombosis and Thrombolysis

JF - Journal of Thrombosis and Thrombolysis

SN - 0929-5305

IS - 1

ER -