Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu, Steven P. McLaughlin, A. A.Leslie Gunatilaka

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

Original languageEnglish (US)
Pages (from-to)2045-2048
Number of pages4
JournalJournal Of Natural Products
Volume70
Issue number12
DOIs
StatePublished - Dec 1 2007

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this