Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia

Ya Ming Xu, Steven P. McLaughlin, Leslie Gunatilaka

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Four new diene valepotriates, sorbifolivaltrates A-D (1-4), and the known compounds isovaltrate (5), valtrate (6), seneciovaltrate (7), valtrate hydrine B3 (8), and valtrate hydrine B7 (9), have been isolated by bioassay-guided fractionation of the cytotoxic hexanes and methyl ethyl ketone crude extracts of the aerial parts of Valeriana sorbifolia occurring in the Sonoran desert. The structures of 1-4 were determined on the basis of their high-resolution mass spectrometric and NMR spectroscopic data. All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M.

Original languageEnglish (US)
Pages (from-to)2045-2048
Number of pages4
JournalJournal of Natural Products
Volume70
Issue number12
DOIs
StatePublished - Dec 2007

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valepotriates
Valerian
Valeriana
Sonoran Desert
prostatic neoplasms
ketones
hexane
aerial parts
cytotoxicity
fractionation
bioassays
cell lines
extracts
Bioassay
Hexanes
Cytotoxicity
Fractionation
Complex Mixtures
Biological Assay
Prostatic Neoplasms

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia. / Xu, Ya Ming; McLaughlin, Steven P.; Gunatilaka, Leslie.

In: Journal of Natural Products, Vol. 70, No. 12, 12.2007, p. 2045-2048.

Research output: Contribution to journalArticle

Xu, Ya Ming ; McLaughlin, Steven P. ; Gunatilaka, Leslie. / Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia. In: Journal of Natural Products. 2007 ; Vol. 70, No. 12. pp. 2045-2048.
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