Spatial patterns of cartilage loss in the medial femoral condyle in osteoarthritic knees: Data from the osteoarthritis initiative

Wolfgang Wirth, Olivier Benichou, C. Kent Kwoh, Ali Guermazi, David Hunter, Reinhard Putz, Felix Eckstein

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

The objective of this study was to develop a technique for analyzing spatial patterns of cartilage loss in the medial femoral condyle (MF), and to study MF cartilage loss in participants of the Osteoarthritis Initiative. Using a 0.7mm sagittal double echo at steady state (DESS) sequence, 160 osteoarthritic knees from 80 participants with varying degrees of medial joint space narrowing were imaged at baseline and 1-year follow-up. MF cartilage was segmented and cartilage loss determined. Rate of change varied significantly (P = 0.0067) along the anterior-posterior extension of the MF, with the greatest changes (-45 μm, -2.7%) observed 30-60° posterior to the trochlear notch. The rate was greater in the central MF after excluding peripheral aspects of the MF from analysis. Sensitivity to change was greatest at 45-75° (standardized response mean = -0.32) but was minimally affected by medial-lateral trimming. In conclusion, the greatest sensitivity to change was achieved when analyzing the posterior aspect of the central, weight-bearing MF.

Original languageEnglish (US)
Pages (from-to)574-581
Number of pages8
JournalMagnetic Resonance in Medicine
Volume63
Issue number3
DOIs
StatePublished - Mar 2010

Keywords

  • 3 tesla
  • Cartilage
  • Image analysis
  • Osteoarthritis
  • Subregions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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