Abstract
The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates with increased migration and invasive capacity. We now report that α6 is cleaved during the normal development of Xenopus in a spatially and temporally controlled manner. In addition, unlike normal mammalian tissues, which lack α6p, the major form of the α6 integrin present in adult Xenopus is α6p. The protease responsible for the cleavage in mammals, uPA, is not involved in the cleavage of Xenopus α6. Finally, overexpression of a mammalian α6 mutant which cannot be cleaved leads to developmental abnormalities suggesting a potential role for the cleavage in development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 779-785 |
| Number of pages | 7 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 366 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 15 2008 |
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Keywords
- Development
- Integrin
- Xenopus laevis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development. / Demetriou, Manolis C.; Stylianou, Panayiota; Andreou, Maria; Yiannikouri, Olga; Tsaprailis, George; Cress, Anne E; Skourides, Paris.
In: Biochemical and Biophysical Research Communications, Vol. 366, No. 3, 15.02.2008, p. 779-785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development
AU - Demetriou, Manolis C.
AU - Stylianou, Panayiota
AU - Andreou, Maria
AU - Yiannikouri, Olga
AU - Tsaprailis, George
AU - Cress, Anne E
AU - Skourides, Paris
PY - 2008/2/15
Y1 - 2008/2/15
N2 - The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates with increased migration and invasive capacity. We now report that α6 is cleaved during the normal development of Xenopus in a spatially and temporally controlled manner. In addition, unlike normal mammalian tissues, which lack α6p, the major form of the α6 integrin present in adult Xenopus is α6p. The protease responsible for the cleavage in mammals, uPA, is not involved in the cleavage of Xenopus α6. Finally, overexpression of a mammalian α6 mutant which cannot be cleaved leads to developmental abnormalities suggesting a potential role for the cleavage in development.
AB - The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates with increased migration and invasive capacity. We now report that α6 is cleaved during the normal development of Xenopus in a spatially and temporally controlled manner. In addition, unlike normal mammalian tissues, which lack α6p, the major form of the α6 integrin present in adult Xenopus is α6p. The protease responsible for the cleavage in mammals, uPA, is not involved in the cleavage of Xenopus α6. Finally, overexpression of a mammalian α6 mutant which cannot be cleaved leads to developmental abnormalities suggesting a potential role for the cleavage in development.
KW - Development
KW - Integrin
KW - Xenopus laevis
UR - http://www.scopus.com/inward/record.url?scp=37549061812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37549061812&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2007.12.040
DO - 10.1016/j.bbrc.2007.12.040
M3 - Article
C2 - 18083114
AN - SCOPUS:37549061812
VL - 366
SP - 779
EP - 785
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -