Spatiotemporal evolution of erythema migrans, the hallmark rash of lyme disease

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To elucidate pathogen-host interactions during early Lyme disease, we developed a mathematical model that explains the spatiotemporal dynamics of the characteristic first sign of the disease, a large (≥5-cm diameter) rash, known as an erythema migrans. The model predicts that the bacterial replication and dissemination rates are the primary factors controlling the speed that the rash spreads, whereas the rate that active macrophages are cleared from the dermis is the principle determinant of rash morphology. In addition, the model supports the clinical observations that antibiotic treatment quickly clears spirochetes from the dermis and that the rash appearance is not indicative of the efficacy of the treatment. The quantitative agreement between our results and clinical data suggest that this model could be used to develop more efficient drug treatments and may form a basis for modeling pathogen-host interactions in other emerging infectious diseases.

Original languageEnglish (US)
Pages (from-to)763-768
Number of pages6
JournalBiophysical Journal
Volume106
Issue number3
DOIs
StatePublished - Feb 4 2014

Fingerprint

Lyme Disease
Erythema
Exanthema
Host-Pathogen Interactions
Dermis
Emerging Communicable Diseases
Spirochaetales
Theoretical Models
Macrophages
Anti-Bacterial Agents
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biophysics

Cite this

Spatiotemporal evolution of erythema migrans, the hallmark rash of lyme disease. / Vig, Dhruv K.; Wolgemuth, Charles William.

In: Biophysical Journal, Vol. 106, No. 3, 04.02.2014, p. 763-768.

Research output: Contribution to journalArticle

@article{84ce8107a2634b1b9e323361e01dffdf,
title = "Spatiotemporal evolution of erythema migrans, the hallmark rash of lyme disease",
abstract = "To elucidate pathogen-host interactions during early Lyme disease, we developed a mathematical model that explains the spatiotemporal dynamics of the characteristic first sign of the disease, a large (≥5-cm diameter) rash, known as an erythema migrans. The model predicts that the bacterial replication and dissemination rates are the primary factors controlling the speed that the rash spreads, whereas the rate that active macrophages are cleared from the dermis is the principle determinant of rash morphology. In addition, the model supports the clinical observations that antibiotic treatment quickly clears spirochetes from the dermis and that the rash appearance is not indicative of the efficacy of the treatment. The quantitative agreement between our results and clinical data suggest that this model could be used to develop more efficient drug treatments and may form a basis for modeling pathogen-host interactions in other emerging infectious diseases.",
author = "Vig, {Dhruv K.} and Wolgemuth, {Charles William}",
year = "2014",
month = "2",
day = "4",
doi = "10.1016/j.bpj.2013.12.017",
language = "English (US)",
volume = "106",
pages = "763--768",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Biophysical Society",
number = "3",

}

TY - JOUR

T1 - Spatiotemporal evolution of erythema migrans, the hallmark rash of lyme disease

AU - Vig, Dhruv K.

AU - Wolgemuth, Charles William

PY - 2014/2/4

Y1 - 2014/2/4

N2 - To elucidate pathogen-host interactions during early Lyme disease, we developed a mathematical model that explains the spatiotemporal dynamics of the characteristic first sign of the disease, a large (≥5-cm diameter) rash, known as an erythema migrans. The model predicts that the bacterial replication and dissemination rates are the primary factors controlling the speed that the rash spreads, whereas the rate that active macrophages are cleared from the dermis is the principle determinant of rash morphology. In addition, the model supports the clinical observations that antibiotic treatment quickly clears spirochetes from the dermis and that the rash appearance is not indicative of the efficacy of the treatment. The quantitative agreement between our results and clinical data suggest that this model could be used to develop more efficient drug treatments and may form a basis for modeling pathogen-host interactions in other emerging infectious diseases.

AB - To elucidate pathogen-host interactions during early Lyme disease, we developed a mathematical model that explains the spatiotemporal dynamics of the characteristic first sign of the disease, a large (≥5-cm diameter) rash, known as an erythema migrans. The model predicts that the bacterial replication and dissemination rates are the primary factors controlling the speed that the rash spreads, whereas the rate that active macrophages are cleared from the dermis is the principle determinant of rash morphology. In addition, the model supports the clinical observations that antibiotic treatment quickly clears spirochetes from the dermis and that the rash appearance is not indicative of the efficacy of the treatment. The quantitative agreement between our results and clinical data suggest that this model could be used to develop more efficient drug treatments and may form a basis for modeling pathogen-host interactions in other emerging infectious diseases.

UR - http://www.scopus.com/inward/record.url?scp=84893479854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893479854&partnerID=8YFLogxK

U2 - 10.1016/j.bpj.2013.12.017

DO - 10.1016/j.bpj.2013.12.017

M3 - Article

C2 - 24507617

AN - SCOPUS:84893479854

VL - 106

SP - 763

EP - 768

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 3

ER -