Specific Inhibition of Lymphocyte Blastogenic Responses to Mitogens by a Factor Produced by Cultured Human Malignant Lymphoma Cells

Evan M. Hersh, Benjamin Drewinko

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A glass-adherent human lymphoma cell line was found to produce an inhibitor of human in vitro lymphocyte blastogenic responses. The responses to mitogens, antigens, and allogeneic leukocytes were inhibited over 90%, as assayed by DNA synthesis or morphology. The effect was not associated with cytotoxicity and was reversible by washing the inhibited cells. The material was a nondialyzable, heatstable protein. Its activity was not affected by its deoxyribonuclease and ribonuclease but was destroyed by Pronase. Most important, the inhibitor was species and tissue specific; it did not inhibit mouse lymphocytes or a variety of human tissue culture cell lines. The relationship of this material to regulation of lymphoid function and to the etiology and pathogenesis of cancer is discussed.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalCancer Research
Volume34
Issue number1
StatePublished - Jan 1974

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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