Abstract
In neonatal rabbit soleus muscle, different motor units were found to contract with widely varying time courses. Analysis of these data suggest that individual motor units are largely homogeneous for muscle fiber type despite the presence of extensive polyinnervation at birth. We suggest that (1) neonatal motor neurons are effectively differentiated into specific types insofar as they preferentially innervate muscle fibers which give rise to different contraction times, and (2) muscle fibers begin their physiological differentiation into twitch types while still polyinnervated. Possible mechanisms underlying the development of a specific pattern of neuromuscular innervation are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 42-50 |
| Number of pages | 9 |
| Journal | Developmental Biology |
| Volume | 111 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Developmental Biology
Cite this
Specific innervation of muscle fiber types in a developmentally polyinnervated muscle. / Gordon, Herman; Van Essen, David C.
In: Developmental Biology, Vol. 111, No. 1, 1985, p. 42-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Specific innervation of muscle fiber types in a developmentally polyinnervated muscle
AU - Gordon, Herman
AU - Van Essen, David C.
PY - 1985
Y1 - 1985
N2 - In neonatal rabbit soleus muscle, different motor units were found to contract with widely varying time courses. Analysis of these data suggest that individual motor units are largely homogeneous for muscle fiber type despite the presence of extensive polyinnervation at birth. We suggest that (1) neonatal motor neurons are effectively differentiated into specific types insofar as they preferentially innervate muscle fibers which give rise to different contraction times, and (2) muscle fibers begin their physiological differentiation into twitch types while still polyinnervated. Possible mechanisms underlying the development of a specific pattern of neuromuscular innervation are discussed.
AB - In neonatal rabbit soleus muscle, different motor units were found to contract with widely varying time courses. Analysis of these data suggest that individual motor units are largely homogeneous for muscle fiber type despite the presence of extensive polyinnervation at birth. We suggest that (1) neonatal motor neurons are effectively differentiated into specific types insofar as they preferentially innervate muscle fibers which give rise to different contraction times, and (2) muscle fibers begin their physiological differentiation into twitch types while still polyinnervated. Possible mechanisms underlying the development of a specific pattern of neuromuscular innervation are discussed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022405698&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(85)90433-6
DO - 10.1016/0012-1606(85)90433-6
M3 - Article
VL - 111
SP - 42
EP - 50
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 1
ER -