Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons

N. E. Rawson, F. W. Lischka, K. K. Yee, A. Z. Peters, E. S. Tucker, D. W. Meechan, M. Zirlinger, T. M. Maynard, G. B. Burd, C. Dulac, L. Pevny, A. S. LaMantia

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin-releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E-mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE-specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons.

Original languageEnglish (US)
Pages (from-to)1723-1738
Number of pages16
JournalDevelopmental Dynamics
Volume239
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Induction
  • Limb bud
  • Neurogenesis
  • Olfactory

ASJC Scopus subject areas

  • Developmental Biology

Fingerprint Dive into the research topics of 'Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons'. Together they form a unique fingerprint.

  • Cite this

    Rawson, N. E., Lischka, F. W., Yee, K. K., Peters, A. Z., Tucker, E. S., Meechan, D. W., Zirlinger, M., Maynard, T. M., Burd, G. B., Dulac, C., Pevny, L., & LaMantia, A. S. (2010). Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. Developmental Dynamics, 239(6), 1723-1738. https://doi.org/10.1002/dvdy.22315