Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons

N. E. Rawson, F. W. Lischka, K. K. Yee, A. Z. Peters, E. S. Tucker, D. W. Meechan, M. Zirlinger, T. M. Maynard, Gail D Burd, C. Dulac, L. Pevny, A. S. LaMantia

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We asked whether specific mesenchymal/epithelial (M/E) induction generates olfactory receptor neurons (ORNs), vomeronasal neurons (VRNs), and gonadotropin-releasing hormone (GnRH) neurons, the major neuron classes associated with the olfactory epithelium (OE). To assess specificity of M/E-mediated neurogenesis, we compared the influence of frontonasal mesenchyme on frontonasal epithelium, which becomes the OE, with that of the forelimb bud. Despite differences in position, morphogenetic and cytogenic capacity, both mesenchymal tissues support neurogenesis, expression of several signaling molecules and neurogenic transcription factors in the frontonasal epithelium. Only frontonasal mesenchyme, however, supports OE-specific patterning and activity of a subset of signals and factors associated with OE differentiation. Moreover, only appropriate pairing of frontonasal epithelial and mesenchymal partners yields ORNs, VRNs, and GnRH neurons. Accordingly, the position and molecular identity of specialized frontonasal epithelia and mesenchyme early in gestation and subsequent inductive interactions specify the genesis and differentiation of peripheral chemosensory and neuroendocrine neurons.

Original languageEnglish (US)
Pages (from-to)1723-1738
Number of pages16
JournalDevelopmental Dynamics
Volume239
Issue number6
DOIs
StatePublished - 2010

Fingerprint

Odorant Receptors
Gonadotropin-Releasing Hormone
Olfactory Mucosa
Neurons
Mesoderm
Olfactory Receptor Neurons
Epithelium
Neurogenesis
Forelimb
Transcription Factors
Pregnancy

Keywords

  • Induction
  • Limb bud
  • Neurogenesis
  • Olfactory

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)

Cite this

Rawson, N. E., Lischka, F. W., Yee, K. K., Peters, A. Z., Tucker, E. S., Meechan, D. W., ... LaMantia, A. S. (2010). Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. Developmental Dynamics, 239(6), 1723-1738. https://doi.org/10.1002/dvdy.22315

Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. / Rawson, N. E.; Lischka, F. W.; Yee, K. K.; Peters, A. Z.; Tucker, E. S.; Meechan, D. W.; Zirlinger, M.; Maynard, T. M.; Burd, Gail D; Dulac, C.; Pevny, L.; LaMantia, A. S.

In: Developmental Dynamics, Vol. 239, No. 6, 2010, p. 1723-1738.

Research output: Contribution to journalArticle

Rawson, NE, Lischka, FW, Yee, KK, Peters, AZ, Tucker, ES, Meechan, DW, Zirlinger, M, Maynard, TM, Burd, GD, Dulac, C, Pevny, L & LaMantia, AS 2010, 'Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons', Developmental Dynamics, vol. 239, no. 6, pp. 1723-1738. https://doi.org/10.1002/dvdy.22315
Rawson, N. E. ; Lischka, F. W. ; Yee, K. K. ; Peters, A. Z. ; Tucker, E. S. ; Meechan, D. W. ; Zirlinger, M. ; Maynard, T. M. ; Burd, Gail D ; Dulac, C. ; Pevny, L. ; LaMantia, A. S. / Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. In: Developmental Dynamics. 2010 ; Vol. 239, No. 6. pp. 1723-1738.
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