Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug

Sirirat Pinsuwan, Fernando A. Alvarez-Núñez, S. Esmail Tabibi, Samuel H Yalkowsky

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A spectrophotometric technique was used to determine the acidity constants of 4-dedimethylamino sancycline (Col-3), a new antitumor drug. The apparent pK(a) values of Col-3 in 0.5% methanol aqueous media at approximately 25 °C with a constant ionic strength of 0.2 were calculated manually and graphically to be 5.64 ± 0.17 (pK(a1)) and 8.35 ± 0.07 (pK(a2)). In addition, the computer program SQUAD was used to confirm Col-3 pK(a) values. The pK(a) values obtained by SQUAD were pK(a1) 5.63 ± 0.14 and pK(a2) 8.39 ± 0.04. These results are in agreement with the tetracycline- like structure of Col-3.

Original languageEnglish (US)
Pages (from-to)535-537
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume88
Issue number5
DOIs
StatePublished - May 1999

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Tetracycline
Ionic strength
Acidity
Antineoplastic Agents
Osmolar Concentration
Methanol
Computer program listings
Software
tetracycline CMT-3

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug. / Pinsuwan, Sirirat; Alvarez-Núñez, Fernando A.; Tabibi, S. Esmail; Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 88, No. 5, 05.1999, p. 535-537.

Research output: Contribution to journalArticle

Pinsuwan, Sirirat ; Alvarez-Núñez, Fernando A. ; Tabibi, S. Esmail ; Yalkowsky, Samuel H. / Spectrophotometric determination of acidity constants of 4- dedimethylamino sancycline (Col-3), a new antitumor drug. In: Journal of Pharmaceutical Sciences. 1999 ; Vol. 88, No. 5. pp. 535-537.
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