Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region

Jonathan S. Berg, Nicola Brunetti-Pierri, Sarika U. Peters, Sung Hae L Kang, Chin To Fong, Jessica Salamone, Debra Freedenberg, Vickie L. Hannig, Lisa Albers Prock, David T. Miller, Peter Raffalli, David J. Harris, Robert P. Erickson, Christopher M Cunniff, Gary D. Clark, Maria A. Blazo, Daniel A. Peiffer, Kevin L. Gunderson, Trilochan Sahoo, Ankita PatelJames R. Lupski, Arthur L. Beaudet, Sau Wai Cheung

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

PURPOSE: Williams-Beuren syndrome is among the most well-characterized microdeletion syndromes, caused by recurrent de novo microdeletions at 7q11.23 mediated by nonallelic homologous recombination between low copy repeats flanking this critical region. However, the clinical phenotype associated with reciprocal microduplication of this genomic region is less well described. We investigated the molecular, clinical, neurodevelopmental, and behavioral features of seven patients with dup(7)(q11.23), including two children who inherited the microduplication from one of their parents, to more fully characterize this emerging microduplication syndrome. METHODS: Patients were identified by array-based comparative genomic hybridization. Clinical examinations were performed on seven affected probands, and detailed cognitive and behavioral evaluations were carried out on four of the affected probands. RESULTS: Our findings confirm initial reports of speech delay seen in patients with dup(7)(q11.23) and further delineate and expand the phenotypic spectrum of this condition to include communication, social interactions, and repetitive interests that are often observed in individuals diagnosed with autism spectrum disorders. CONCLUSIONS: Array-based comparative genomic hybridization is a powerful means of detecting genomic imbalances and identifying molecular etiologies in the clinic setting, including genomic disorders such as Williams-Beuren syndrome and dup(7)(q11.23). We propose that dup(7)(q11.23) syndrome may be as frequent as Williams-Beuren syndrome and a previously unrecognized cause of language delay and behavioral abnormalities. Indeed, these individuals may first be referred for evaluation of autism, even if they do not ultimately meet diagnostic criteria for an autism spectrum disorder.

Original languageEnglish (US)
Pages (from-to)427-441
Number of pages15
JournalGenetics in medicine : official journal of the American College of Medical Genetics
Volume9
Issue number7
DOIs
StatePublished - Jul 2007

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Williams Syndrome
Language Development Disorders
Autistic Disorder
Comparative Genomic Hybridization
Genomic Segmental Duplications
Homologous Recombination
Interpersonal Relations
Parents
Communication
Phenotype
Williams-Beuren Region Duplication Syndrome
Autism Spectrum Disorder

Keywords

  • 7q11.23
  • Autism spectrum disorder
  • Language delay
  • Microduplication

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. / Berg, Jonathan S.; Brunetti-Pierri, Nicola; Peters, Sarika U.; Kang, Sung Hae L; Fong, Chin To; Salamone, Jessica; Freedenberg, Debra; Hannig, Vickie L.; Prock, Lisa Albers; Miller, David T.; Raffalli, Peter; Harris, David J.; Erickson, Robert P.; Cunniff, Christopher M; Clark, Gary D.; Blazo, Maria A.; Peiffer, Daniel A.; Gunderson, Kevin L.; Sahoo, Trilochan; Patel, Ankita; Lupski, James R.; Beaudet, Arthur L.; Cheung, Sau Wai.

In: Genetics in medicine : official journal of the American College of Medical Genetics, Vol. 9, No. 7, 07.2007, p. 427-441.

Research output: Contribution to journalArticle

Berg, JS, Brunetti-Pierri, N, Peters, SU, Kang, SHL, Fong, CT, Salamone, J, Freedenberg, D, Hannig, VL, Prock, LA, Miller, DT, Raffalli, P, Harris, DJ, Erickson, RP, Cunniff, CM, Clark, GD, Blazo, MA, Peiffer, DA, Gunderson, KL, Sahoo, T, Patel, A, Lupski, JR, Beaudet, AL & Cheung, SW 2007, 'Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region', Genetics in medicine : official journal of the American College of Medical Genetics, vol. 9, no. 7, pp. 427-441. https://doi.org/10.1097/GIM.0b013e3180986192
Berg, Jonathan S. ; Brunetti-Pierri, Nicola ; Peters, Sarika U. ; Kang, Sung Hae L ; Fong, Chin To ; Salamone, Jessica ; Freedenberg, Debra ; Hannig, Vickie L. ; Prock, Lisa Albers ; Miller, David T. ; Raffalli, Peter ; Harris, David J. ; Erickson, Robert P. ; Cunniff, Christopher M ; Clark, Gary D. ; Blazo, Maria A. ; Peiffer, Daniel A. ; Gunderson, Kevin L. ; Sahoo, Trilochan ; Patel, Ankita ; Lupski, James R. ; Beaudet, Arthur L. ; Cheung, Sau Wai. / Speech delay and autism spectrum behaviors are frequently associated with duplication of the 7q11.23 Williams-Beuren syndrome region. In: Genetics in medicine : official journal of the American College of Medical Genetics. 2007 ; Vol. 9, No. 7. pp. 427-441.
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AU - Berg, Jonathan S.

AU - Brunetti-Pierri, Nicola

AU - Peters, Sarika U.

AU - Kang, Sung Hae L

AU - Fong, Chin To

AU - Salamone, Jessica

AU - Freedenberg, Debra

AU - Hannig, Vickie L.

AU - Prock, Lisa Albers

AU - Miller, David T.

AU - Raffalli, Peter

AU - Harris, David J.

AU - Erickson, Robert P.

AU - Cunniff, Christopher M

AU - Clark, Gary D.

AU - Blazo, Maria A.

AU - Peiffer, Daniel A.

AU - Gunderson, Kevin L.

AU - Sahoo, Trilochan

AU - Patel, Ankita

AU - Lupski, James R.

AU - Beaudet, Arthur L.

AU - Cheung, Sau Wai

PY - 2007/7

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N2 - PURPOSE: Williams-Beuren syndrome is among the most well-characterized microdeletion syndromes, caused by recurrent de novo microdeletions at 7q11.23 mediated by nonallelic homologous recombination between low copy repeats flanking this critical region. However, the clinical phenotype associated with reciprocal microduplication of this genomic region is less well described. We investigated the molecular, clinical, neurodevelopmental, and behavioral features of seven patients with dup(7)(q11.23), including two children who inherited the microduplication from one of their parents, to more fully characterize this emerging microduplication syndrome. METHODS: Patients were identified by array-based comparative genomic hybridization. Clinical examinations were performed on seven affected probands, and detailed cognitive and behavioral evaluations were carried out on four of the affected probands. RESULTS: Our findings confirm initial reports of speech delay seen in patients with dup(7)(q11.23) and further delineate and expand the phenotypic spectrum of this condition to include communication, social interactions, and repetitive interests that are often observed in individuals diagnosed with autism spectrum disorders. CONCLUSIONS: Array-based comparative genomic hybridization is a powerful means of detecting genomic imbalances and identifying molecular etiologies in the clinic setting, including genomic disorders such as Williams-Beuren syndrome and dup(7)(q11.23). We propose that dup(7)(q11.23) syndrome may be as frequent as Williams-Beuren syndrome and a previously unrecognized cause of language delay and behavioral abnormalities. Indeed, these individuals may first be referred for evaluation of autism, even if they do not ultimately meet diagnostic criteria for an autism spectrum disorder.

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