Spermine induces haemoglobin synthesis in murine erythroleukaemia cells

J. G. Delcros, B. Schwartz, S. Clement, H. S. Basu, L. J. Marton, B. G. Feuerstein

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.

Original languageEnglish (US)
Pages (from-to)781-786
Number of pages6
JournalBiochemical Journal
Volume309
Issue number3
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Delcros, J. G., Schwartz, B., Clement, S., Basu, H. S., Marton, L. J., & Feuerstein, B. G. (1995). Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. Biochemical Journal, 309(3), 781-786. https://doi.org/10.1042/bj3090781