Abstract
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
Original language | English (US) |
---|---|
Pages (from-to) | 781-786 |
Number of pages | 6 |
Journal | Biochemical Journal |
Volume | 309 |
Issue number | 3 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology