Spermine induces haemoglobin synthesis in murine erythroleukaemia cells

J. G. Delcros, B. Schwartz, S. Clement, H. S. Basu, L. J. Marton, Burt G.F. Feuerstein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.

Original languageEnglish (US)
Pages (from-to)781-786
Number of pages6
JournalBiochemical Journal
Volume309
Issue number3
StatePublished - 1995
Externally publishedYes

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Leukemia, Erythroblastic, Acute
Spermine
Hemoglobins
Cell Size
Globins
Polyamines
Cell Cycle
Cells
Messenger RNA
Growth

ASJC Scopus subject areas

  • Biochemistry

Cite this

Delcros, J. G., Schwartz, B., Clement, S., Basu, H. S., Marton, L. J., & Feuerstein, B. G. F. (1995). Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. Biochemical Journal, 309(3), 781-786.

Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. / Delcros, J. G.; Schwartz, B.; Clement, S.; Basu, H. S.; Marton, L. J.; Feuerstein, Burt G.F.

In: Biochemical Journal, Vol. 309, No. 3, 1995, p. 781-786.

Research output: Contribution to journalArticle

Delcros, JG, Schwartz, B, Clement, S, Basu, HS, Marton, LJ & Feuerstein, BGF 1995, 'Spermine induces haemoglobin synthesis in murine erythroleukaemia cells', Biochemical Journal, vol. 309, no. 3, pp. 781-786.
Delcros JG, Schwartz B, Clement S, Basu HS, Marton LJ, Feuerstein BGF. Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. Biochemical Journal. 1995;309(3):781-786.
Delcros, J. G. ; Schwartz, B. ; Clement, S. ; Basu, H. S. ; Marton, L. J. ; Feuerstein, Burt G.F. / Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. In: Biochemical Journal. 1995 ; Vol. 309, No. 3. pp. 781-786.
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