Abstract
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 781-786 |
| Number of pages | 6 |
| Journal | Biochemical Journal |
| Volume | 309 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1995 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Delcros, J. G., Schwartz, B., Clement, S., Basu, H. S., Marton, L. J., & Feuerstein, B. G. (1995). Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. Biochemical Journal, 309(3), 781-786. https://doi.org/10.1042/bj3090781