Abstract
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 781-786 |
| Number of pages | 6 |
| Journal | Biochemical Journal |
| Volume | 309 |
| Issue number | 3 |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
Cite this
Spermine induces haemoglobin synthesis in murine erythroleukaemia cells. / Delcros, J. G.; Schwartz, B.; Clement, S.; Basu, H. S.; Marton, L. J.; Feuerstein, Burt G.F.
In: Biochemical Journal, Vol. 309, No. 3, 1995, p. 781-786.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Spermine induces haemoglobin synthesis in murine erythroleukaemia cells
AU - Delcros, J. G.
AU - Schwartz, B.
AU - Clement, S.
AU - Basu, H. S.
AU - Marton, L. J.
AU - Feuerstein, Burt G.F.
PY - 1995
Y1 - 1995
N2 - The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
AB - The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
UR - http://www.scopus.com/inward/record.url?scp=0029117651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029117651&partnerID=8YFLogxK
M3 - Article
C2 - 7639693
AN - SCOPUS:0029117651
VL - 309
SP - 781
EP - 786
JO - Biochemical Journal
JF - Biochemical Journal
SN - 0264-6021
IS - 3
ER -