Spermine induces haemoglobin synthesis in murine erythroleukaemia cells

J. G. Delcros, B. Schwartz, S. Clement, H. S. Basu, L. J. Marton, B. G. Feuerstein

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic β-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylenebisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.

Original languageEnglish (US)
Pages (from-to)781-786
Number of pages6
JournalBiochemical Journal
Volume309
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Spermine induces haemoglobin synthesis in murine erythroleukaemia cells'. Together they form a unique fingerprint.

Cite this