Spider, bacterial and fungal phospholipase D toxins make cyclic phosphate products

Daniel M. Lajoie, Matthew Hj Cordes

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Phospholipase D (PLD) toxins from sicariid spiders, which cause disease in mammals, were recently found to convert their primary substrates, sphingomyelin and lysophosphatidylcholine, to cyclic phospholipids. Here we show that two PLD toxins from pathogenic actinobacteria and ascomycete fungi, which share distant homology with the spider toxins, also generate cyclic phospholipids. This shared function supports divergent evolution of the PLD toxins from a common ancestor and suggests the importance of cyclic phospholipids in pathogenicity.

Original languageEnglish (US)
Pages (from-to)176-180
Number of pages5
JournalToxicon
Volume108
DOIs
Publication statusPublished - Dec 15 2015

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Keywords

  • P-NMR
  • Arcanobacterium haemolyticum
  • Coccidioides posadasii
  • Phospholipase D
  • Toxin evolution

ASJC Scopus subject areas

  • Toxicology

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