Spinal neurons involved in the generation of at-level pain following spinal injury in the rat

Robert P. Yezierski, Chen Guang Yu, Patrick W Mantyh, Charles J. Vierck, Douglas A. Lappi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Using a conjugate of substance P and the ribosome-inactivating protein saporin, neurons expressing the neurokinin-1 receptor in lamina I of the spinal cord were targeted to determine their role in the expression of a spontaneous pain behavior following intraspinal injections of quisqualic acid in the rat. Treatment was carried out at the time of injury in order to prevent the onset of the behavior, and following onset in order to evaluate the potential clinical utility of this intervention. Treatment at the time of injury resulted in significant decreases in onset-time and severity of pain behavior, while treatment at the time of onset led to a significant reduction of the spontaneous self-directed behavior. The results suggest that the substrate for at-level pain following spinal cord injury includes a population of spinal neurons expressing the neurokinin-1 receptor in the superficial laminae of the spinal cord.

Original languageEnglish (US)
Pages (from-to)232-236
Number of pages5
JournalNeuroscience Letters
Volume361
Issue number1-3
DOIs
StatePublished - May 6 2004
Externally publishedYes

Fingerprint

Spinal Injuries
Neurokinin-1 Receptors
Neurons
Pain
Spinal Cord
Ribosome Inactivating Proteins
Quisqualic Acid
Spinal Injections
Wounds and Injuries
Substance P
Spinal Cord Injuries
Therapeutics
Population

Keywords

  • Central pain
  • Excitotoxicity
  • Lamina I
  • Quisqualic acid
  • Saporin
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spinal neurons involved in the generation of at-level pain following spinal injury in the rat. / Yezierski, Robert P.; Yu, Chen Guang; Mantyh, Patrick W; Vierck, Charles J.; Lappi, Douglas A.

In: Neuroscience Letters, Vol. 361, No. 1-3, 06.05.2004, p. 232-236.

Research output: Contribution to journalArticle

Yezierski, Robert P. ; Yu, Chen Guang ; Mantyh, Patrick W ; Vierck, Charles J. ; Lappi, Douglas A. / Spinal neurons involved in the generation of at-level pain following spinal injury in the rat. In: Neuroscience Letters. 2004 ; Vol. 361, No. 1-3. pp. 232-236.
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