Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy

Meyer Kattan, Leonard B. Bacharier, George T. O'Connor, Robyn Cohen, Ronald L. Sorkness, Wayne Morgan, Peter J. Gergen, Katy F. Jaffee, Cynthia M. Visness, Robert A. Wood, Gordon R. Bloomberg, Susan Doyle, Ryan Burton, James E. Gern

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Comparisons of the technical acceptability of spirometry and impulse oscillometry (IOS) and clinical correlations of the measurements have not been well studied in young children. There are no large studies focused on African American and Hispanic children. Objectives: We sought to (1) compare the acceptability of spirometry and IOS in 3- to 5-year-old children and (2) examine the relationship of maternal smoking during pregnancy to later lung function. Methods: Spirometry and IOS were attempted at 4 sites from the Urban Environmental and Childhood Asthma Study birth cohort at ages 3, 4, and 5 years (472, 471, and 479 children, respectively). We measured forced expiratory flow in 0.5 s (forced expiratory volume in 0.5 seconds [FEV0.5]) with spirometry and area of reactance (A X ), resistance and reactance at 5 Hz (R 5 and X 5, respectively) using IOS. Results: Children were more likely to achieve acceptable maneuvers with spirometry than with IOS at age 3 (60% vs 46%, P < .001) and 5 years (89% vs 84%, P = .02). Performance was consistent among the 4 study sites. In children without recurrent wheeze, there were strong trends for higher FEV0.5 and lower R 5 and A X over time. Maternal smoking during pregnancy was associated with higher A X at ages 4 and 5 years (P < .01 for both years). There was no significant difference in FEV0.5 between children with and without in utero exposure to smoking. Conclusion: There is a higher rate of acceptable maneuvers with spirometry compared with IOS, but IOS may be a better indicator of peripheral airway function in preschool children.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology: In Practice
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Oscillometry
Spirometry
Preschool Children
Smoking
Mothers
Pregnancy
Forced Expiratory Volume
Hispanic Americans
African Americans
Cohort Studies
Asthma
Parturition
Lung

Keywords

  • African American
  • Epidemiology
  • Forced oscillation technique
  • Hispanic
  • Pediatric pulmonary function testing
  • Wheezing

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Spirometry and Impulse Oscillometry in Preschool Children : Acceptability and Relationship to Maternal Smoking in Pregnancy. / Kattan, Meyer; Bacharier, Leonard B.; O'Connor, George T.; Cohen, Robyn; Sorkness, Ronald L.; Morgan, Wayne; Gergen, Peter J.; Jaffee, Katy F.; Visness, Cynthia M.; Wood, Robert A.; Bloomberg, Gordon R.; Doyle, Susan; Burton, Ryan; Gern, James E.

In: Journal of Allergy and Clinical Immunology: In Practice, 01.01.2018.

Research output: Contribution to journalArticle

Kattan, M, Bacharier, LB, O'Connor, GT, Cohen, R, Sorkness, RL, Morgan, W, Gergen, PJ, Jaffee, KF, Visness, CM, Wood, RA, Bloomberg, GR, Doyle, S, Burton, R & Gern, JE 2018, 'Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy', Journal of Allergy and Clinical Immunology: In Practice. https://doi.org/10.1016/j.jaip.2017.12.028
Kattan, Meyer ; Bacharier, Leonard B. ; O'Connor, George T. ; Cohen, Robyn ; Sorkness, Ronald L. ; Morgan, Wayne ; Gergen, Peter J. ; Jaffee, Katy F. ; Visness, Cynthia M. ; Wood, Robert A. ; Bloomberg, Gordon R. ; Doyle, Susan ; Burton, Ryan ; Gern, James E. / Spirometry and Impulse Oscillometry in Preschool Children : Acceptability and Relationship to Maternal Smoking in Pregnancy. In: Journal of Allergy and Clinical Immunology: In Practice. 2018.
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abstract = "Background: Comparisons of the technical acceptability of spirometry and impulse oscillometry (IOS) and clinical correlations of the measurements have not been well studied in young children. There are no large studies focused on African American and Hispanic children. Objectives: We sought to (1) compare the acceptability of spirometry and IOS in 3- to 5-year-old children and (2) examine the relationship of maternal smoking during pregnancy to later lung function. Methods: Spirometry and IOS were attempted at 4 sites from the Urban Environmental and Childhood Asthma Study birth cohort at ages 3, 4, and 5 years (472, 471, and 479 children, respectively). We measured forced expiratory flow in 0.5 s (forced expiratory volume in 0.5 seconds [FEV0.5]) with spirometry and area of reactance (A X ), resistance and reactance at 5 Hz (R 5 and X 5, respectively) using IOS. Results: Children were more likely to achieve acceptable maneuvers with spirometry than with IOS at age 3 (60{\%} vs 46{\%}, P < .001) and 5 years (89{\%} vs 84{\%}, P = .02). Performance was consistent among the 4 study sites. In children without recurrent wheeze, there were strong trends for higher FEV0.5 and lower R 5 and A X over time. Maternal smoking during pregnancy was associated with higher A X at ages 4 and 5 years (P < .01 for both years). There was no significant difference in FEV0.5 between children with and without in utero exposure to smoking. Conclusion: There is a higher rate of acceptable maneuvers with spirometry compared with IOS, but IOS may be a better indicator of peripheral airway function in preschool children.",
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T2 - Acceptability and Relationship to Maternal Smoking in Pregnancy

AU - Kattan, Meyer

AU - Bacharier, Leonard B.

AU - O'Connor, George T.

AU - Cohen, Robyn

AU - Sorkness, Ronald L.

AU - Morgan, Wayne

AU - Gergen, Peter J.

AU - Jaffee, Katy F.

AU - Visness, Cynthia M.

AU - Wood, Robert A.

AU - Bloomberg, Gordon R.

AU - Doyle, Susan

AU - Burton, Ryan

AU - Gern, James E.

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N2 - Background: Comparisons of the technical acceptability of spirometry and impulse oscillometry (IOS) and clinical correlations of the measurements have not been well studied in young children. There are no large studies focused on African American and Hispanic children. Objectives: We sought to (1) compare the acceptability of spirometry and IOS in 3- to 5-year-old children and (2) examine the relationship of maternal smoking during pregnancy to later lung function. Methods: Spirometry and IOS were attempted at 4 sites from the Urban Environmental and Childhood Asthma Study birth cohort at ages 3, 4, and 5 years (472, 471, and 479 children, respectively). We measured forced expiratory flow in 0.5 s (forced expiratory volume in 0.5 seconds [FEV0.5]) with spirometry and area of reactance (A X ), resistance and reactance at 5 Hz (R 5 and X 5, respectively) using IOS. Results: Children were more likely to achieve acceptable maneuvers with spirometry than with IOS at age 3 (60% vs 46%, P < .001) and 5 years (89% vs 84%, P = .02). Performance was consistent among the 4 study sites. In children without recurrent wheeze, there were strong trends for higher FEV0.5 and lower R 5 and A X over time. Maternal smoking during pregnancy was associated with higher A X at ages 4 and 5 years (P < .01 for both years). There was no significant difference in FEV0.5 between children with and without in utero exposure to smoking. Conclusion: There is a higher rate of acceptable maneuvers with spirometry compared with IOS, but IOS may be a better indicator of peripheral airway function in preschool children.

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KW - Forced oscillation technique

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KW - Pediatric pulmonary function testing

KW - Wheezing

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