Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia

K. L. Wellish, Marlys H Witte, C. L. Witte, D. B. Van Wyck, K. V. Kinter, R. M. Hagaman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The efficacy of Corynebacterium parvum to stimulate splenic growth and to boost host survival was examined by using adult Sprague-Dawley rats in a highly spleen-sensitive model of fulminant pneumococcemia. Rats were either treated (10 days or 1 hr before or 1 hr after) or not treated with C. parvum; were depleted of complement; underwent partial, total, or sham splenic resection; and then were challenged with either a low (2 x 102) or a high (2 x 105) dose of pneumococci. In the absence of C. parvum, survival (percent and duration) was lowest after total splenectomy and was proportional to remnant spleen weight after partial splenectomy. Although C. parvum treatment sharply increased splenic weight, nucleated cell numbers, and survival, the lowered mortality and improved survival time were independent of spleen weight. The rapidly acting, extrasplenic, splenomimetic protective effect of C. parvum suggests that this class of immunomodulators may be a useful adjunct in managing sepsis associated with defective or absent splenic function.

Original languageEnglish (US)
Pages (from-to)130-135
Number of pages6
JournalJournal of Infectious Diseases
Volume156
Issue number1
StatePublished - 1987

Fingerprint

Propionibacterium acnes
Spleen
Splenectomy
Weights and Measures
Immunologic Factors
Streptococcus pneumoniae
Sprague Dawley Rats
Cell Survival
Sepsis
Cell Count
Mortality
Growth

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Wellish, K. L., Witte, M. H., Witte, C. L., Van Wyck, D. B., Kinter, K. V., & Hagaman, R. M. (1987). Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia. Journal of Infectious Diseases, 156(1), 130-135.

Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia. / Wellish, K. L.; Witte, Marlys H; Witte, C. L.; Van Wyck, D. B.; Kinter, K. V.; Hagaman, R. M.

In: Journal of Infectious Diseases, Vol. 156, No. 1, 1987, p. 130-135.

Research output: Contribution to journalArticle

Wellish, KL, Witte, MH, Witte, CL, Van Wyck, DB, Kinter, KV & Hagaman, RM 1987, 'Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia', Journal of Infectious Diseases, vol. 156, no. 1, pp. 130-135.
Wellish KL, Witte MH, Witte CL, Van Wyck DB, Kinter KV, Hagaman RM. Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia. Journal of Infectious Diseases. 1987;156(1):130-135.
Wellish, K. L. ; Witte, Marlys H ; Witte, C. L. ; Van Wyck, D. B. ; Kinter, K. V. ; Hagaman, R. M. / Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia. In: Journal of Infectious Diseases. 1987 ; Vol. 156, No. 1. pp. 130-135.
@article{da160fc4351146e2923ea7f9bb4ce0f0,
title = "Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia",
abstract = "The efficacy of Corynebacterium parvum to stimulate splenic growth and to boost host survival was examined by using adult Sprague-Dawley rats in a highly spleen-sensitive model of fulminant pneumococcemia. Rats were either treated (10 days or 1 hr before or 1 hr after) or not treated with C. parvum; were depleted of complement; underwent partial, total, or sham splenic resection; and then were challenged with either a low (2 x 102) or a high (2 x 105) dose of pneumococci. In the absence of C. parvum, survival (percent and duration) was lowest after total splenectomy and was proportional to remnant spleen weight after partial splenectomy. Although C. parvum treatment sharply increased splenic weight, nucleated cell numbers, and survival, the lowered mortality and improved survival time were independent of spleen weight. The rapidly acting, extrasplenic, splenomimetic protective effect of C. parvum suggests that this class of immunomodulators may be a useful adjunct in managing sepsis associated with defective or absent splenic function.",
author = "Wellish, {K. L.} and Witte, {Marlys H} and Witte, {C. L.} and {Van Wyck}, {D. B.} and Kinter, {K. V.} and Hagaman, {R. M.}",
year = "1987",
language = "English (US)",
volume = "156",
pages = "130--135",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Splenomimetic effect of Corynebacterium parvum in fulminant pneumococcemia

AU - Wellish, K. L.

AU - Witte, Marlys H

AU - Witte, C. L.

AU - Van Wyck, D. B.

AU - Kinter, K. V.

AU - Hagaman, R. M.

PY - 1987

Y1 - 1987

N2 - The efficacy of Corynebacterium parvum to stimulate splenic growth and to boost host survival was examined by using adult Sprague-Dawley rats in a highly spleen-sensitive model of fulminant pneumococcemia. Rats were either treated (10 days or 1 hr before or 1 hr after) or not treated with C. parvum; were depleted of complement; underwent partial, total, or sham splenic resection; and then were challenged with either a low (2 x 102) or a high (2 x 105) dose of pneumococci. In the absence of C. parvum, survival (percent and duration) was lowest after total splenectomy and was proportional to remnant spleen weight after partial splenectomy. Although C. parvum treatment sharply increased splenic weight, nucleated cell numbers, and survival, the lowered mortality and improved survival time were independent of spleen weight. The rapidly acting, extrasplenic, splenomimetic protective effect of C. parvum suggests that this class of immunomodulators may be a useful adjunct in managing sepsis associated with defective or absent splenic function.

AB - The efficacy of Corynebacterium parvum to stimulate splenic growth and to boost host survival was examined by using adult Sprague-Dawley rats in a highly spleen-sensitive model of fulminant pneumococcemia. Rats were either treated (10 days or 1 hr before or 1 hr after) or not treated with C. parvum; were depleted of complement; underwent partial, total, or sham splenic resection; and then were challenged with either a low (2 x 102) or a high (2 x 105) dose of pneumococci. In the absence of C. parvum, survival (percent and duration) was lowest after total splenectomy and was proportional to remnant spleen weight after partial splenectomy. Although C. parvum treatment sharply increased splenic weight, nucleated cell numbers, and survival, the lowered mortality and improved survival time were independent of spleen weight. The rapidly acting, extrasplenic, splenomimetic protective effect of C. parvum suggests that this class of immunomodulators may be a useful adjunct in managing sepsis associated with defective or absent splenic function.

UR - http://www.scopus.com/inward/record.url?scp=0023213241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023213241&partnerID=8YFLogxK

M3 - Article

VL - 156

SP - 130

EP - 135

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -