Split Liver Transplantation for Two Adult Recipients: An Initial Experience

Abhinav Humar, Thiagarajan Ramcharan, Timothy D. Sielaff, Raja Kandaswamy, Rainer W G Gruessner, John R. Lake, William D. Payne

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82 Scopus citations

Abstract

The shortage of cadaver donor livers has been most severe for adult patients. Split liver transplantation is one method to expand the donor pool, but to have a significant impact on the waiting list, it needs to be applied for 2 adult recipients. We split livers from 6 cadaver donors, and transplanted 12 adult recipients. All splits were performed in situ with transaction through the midplane of the liver, resulting in a right lobe and a left lobe graft. Mean donor age was 19.7years; mean donor weight was 79.1 kg. Mean recipient age was 41.5years. Mean weight of right lobe recipients was 89kg; left lobe recipients, 60kg. All donors were hemodynamically stable and had normal liver function tests. Mean operative time for the procurement was 7.4h. Average blood loss during the transaction of the liver was 490mL. Mean GW/RW ratio for all recipients was 0.87%; right lobe recipients, 0.86%; and left lobe recipients, 0.88%. With mean follow-up of 9.3 months, patient and graft survival rates were both 83.3%. There were 2 deaths: 1 after hepatic artery thrombosis (HAT) and subsequent multiorgan failure; the other after HAT, a liver retransplant, and subsequent gram-negative sepsis. The remaining 10 recipients are doing well. We observed no cases of primary nonfunction. Other complications included bile leak and/or stenosis (n = 3), bleeding from the Roux loop (n = 1), bleeding after percutaneous biopsy (n = 1), and incisional hernia (n = 1). In conclusion, split liver transplantation, using 1 cadaver liver for 2 adult recipients, can be performed successfully. Crucial to success is proper donor and recipient selection.

Original languageEnglish (US)
Pages (from-to)366-372
Number of pages7
JournalAmerican Journal of Transplantation
Volume1
Issue number4
DOIs
Publication statusPublished - Nov 2001
Externally publishedYes

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Keywords

  • Adult recipients
  • Split liver transplantation

ASJC Scopus subject areas

  • Immunology

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