Most sudden cardiac deaths in man are associated with events causing myocardial ischemia and only 40-60% of these patients are successfully resuscitated. Further progress in reducing the mortality from such events will depend on a better understanding of the interventions used during CPR. Animal models currently used for the study of CPR do not involve myocardial ischemia. A new model of cardiac arrest (spontaneous ischemic ventricular fibrillation) in closed-chest dogs resembles more closely the events occurring in man. Initial controlled, randomized studies of the model demonstrate that it repsonds to resuscitation in a manner similar to human resuscitation. Further study of this model during CPR may lead to changes in patient care which will improve survival from episodes of sudden cardiac death.
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine