Squeezing of red blood cells through capillaries with near-minimal diameters

Research output: Contribution to journalArticle

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Abstract

An analysis is presented of the mechanics of red blood cells flowing in very narrow tubes. The changes in cell shape and the resulting rheological parameters are analysed using matched asymptotic expansions for the high-velocity limit and using numerical solutions. Predictions of rheological parameters are also obtained using the assumption that the cell is effectively rigid with its critical shape, yielding very similar results. A rapid decrease in the apparent viscosity of red cell suspensions with increasing tube diameter is predicted over the range of diameters considered. The red cell velocity is found to exceed the mean bulk velocity by an amount that increases with increasing tube diameter.

Original languageEnglish (US)
Pages (from-to)381-400
Number of pages20
JournalJournal of Fluid Mechanics
Volume203
StatePublished - Jun 1989

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erythrocytes
compressing
Blood
Cells
tubes
cells
Mechanics
Viscosity
viscosity
expansion
predictions

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanics of Materials
  • Physics and Astronomy(all)
  • Condensed Matter Physics

Cite this

Squeezing of red blood cells through capillaries with near-minimal diameters. / Secomb, Timothy W.

In: Journal of Fluid Mechanics, Vol. 203, 06.1989, p. 381-400.

Research output: Contribution to journalArticle

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