Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol

Warunee Srisiri, Alto Benedicto, David F. O'Brien, Theodore "Ted" Trouard, Greger Orädd, Stefan Persson, Göran Lindblom

Research output: Contribution to journalArticle

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Abstract

Technological applications of lipids may be possible through stabilization of various liquid-crystalline phases. One important approach to stabilized self-assembling materials utilizes polymerization of liquid-crystalline phases composed of reactive lipids. Polymerization of lipids has been utilized to modify the chemical and physical properties of lamellar assemblies (e.g., lipid monolayers, multilayers, and bilayer vesicles). In addition, polymerization of the lipid region of three-dimensional nonlamellar lipid-phase structures has recently been reported, including the reversed bicontinuous cubic (QII) phase, belonging to the space group Pn3m and the reversed hexagonal (HII) phase. Here we show that an easily prepared polymerizable monoacylglycerol combined in a 9/1 molar ratio with the corresponding polymerizable 1,2-diacylglycerol forms nonlamellar phases upon hydration at room temperature. Phase investigation using cross-polarized light, 2H NMR spectroscopy, and X-ray diffraction showed that the lipid mixture formed a well-defined cubic phase from at least 5 to 45 °C. The X-ray diffraction pattern corresponded to a cubic phase with Ia3d symmetry and a unit cell size of 131 Å at 25 °C. Polymerization to high conversion of this cubic phase was accomplished via the thermal decomposition of H2O2. The resultant polymers dissolved in organic solvent, indicating they were not cross-linked. The visual clear character, cross-polarized light test, and X-ray diffraction showed that isotropic architecture was maintained up to at least 70 °C after sample polymerization. The diffusion coefficient of water (23 °C) within the polymerized cubic phase, determined by pulsed field gradient NMR spectroscopy, was 1.2 ± 0.2 × 10-10m2/s, a value consistent with retention of the cubic phase during and after the polymerization. The biocompatible and mesoporous nature of the polymerized cubic phase suggests it could be used as the host for incorporation of synthetic or biological molecules in a manner that has already proven especially useful in microporous solids.

Original languageEnglish (US)
Pages (from-to)1921-1926
Number of pages6
JournalLangmuir
Volume14
Issue number7
StatePublished - Mar 31 1998

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Monoglycerides
Diglycerides
Lipids
lipids
Stabilization
stabilization
polymerization
Polymerization
Light polarization
X ray diffraction
polarized light
Nuclear magnetic resonance spectroscopy
Crystalline materials
nuclear magnetic resonance
x rays
Liquids
Phase structure
liquids
assembling
diffraction

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Srisiri, W., Benedicto, A., O'Brien, D. F., Trouard, T. T., Orädd, G., Persson, S., & Lindblom, G. (1998). Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol. Langmuir, 14(7), 1921-1926.

Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol. / Srisiri, Warunee; Benedicto, Alto; O'Brien, David F.; Trouard, Theodore "Ted"; Orädd, Greger; Persson, Stefan; Lindblom, Göran.

In: Langmuir, Vol. 14, No. 7, 31.03.1998, p. 1921-1926.

Research output: Contribution to journalArticle

Srisiri, W, Benedicto, A, O'Brien, DF, Trouard, TT, Orädd, G, Persson, S & Lindblom, G 1998, 'Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol', Langmuir, vol. 14, no. 7, pp. 1921-1926.
Srisiri W, Benedicto A, O'Brien DF, Trouard TT, Orädd G, Persson S et al. Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol. Langmuir. 1998 Mar 31;14(7):1921-1926.
Srisiri, Warunee ; Benedicto, Alto ; O'Brien, David F. ; Trouard, Theodore "Ted" ; Orädd, Greger ; Persson, Stefan ; Lindblom, Göran. / Stabilization of a bicontinuous cubic phase from polymerizable monoacylglycerol and diacylglycerol. In: Langmuir. 1998 ; Vol. 14, No. 7. pp. 1921-1926.
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