Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent

Zhiliang Cheng, Ajlan Al Zaki, Ian W. Jones, Henry K. Hall, Craig A Aspinwall, Andrew Tsourkas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.

Original languageEnglish (US)
Pages (from-to)2502-2504
Number of pages3
JournalChemical Communications
Volume50
Issue number19
DOIs
StatePublished - Mar 7 2014

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Dextran
Liposomes
Dextrans
Magnetic resonance imaging
Contrast Media
Membranes
Gadolinium
Magnetic resonance
Polymers
Imaging techniques

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent. / Cheng, Zhiliang; Al Zaki, Ajlan; Jones, Ian W.; Hall, Henry K.; Aspinwall, Craig A; Tsourkas, Andrew.

In: Chemical Communications, Vol. 50, No. 19, 07.03.2014, p. 2502-2504.

Research output: Contribution to journalArticle

Cheng, Zhiliang ; Al Zaki, Ajlan ; Jones, Ian W. ; Hall, Henry K. ; Aspinwall, Craig A ; Tsourkas, Andrew. / Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent. In: Chemical Communications. 2014 ; Vol. 50, No. 19. pp. 2502-2504.
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