Status of liposomes as MR contrast agents

Evan C. Unger, De‐Kang ‐K Shen, Thomas A. Fritz

Research output: Contribution to journalReview article

32 Scopus citations

Abstract

Recent work on the development of liposomal magnetic resonance (MR) contrast agents has yielded structures with higher overall relaxivity than that of other nanoparti‐cles of similar diameter. Liposomes incorporating membrane‐bound complexes of manganese (“memsomes”) produce greater hepatic enhancement per micromole of metal ion than either ferrite particles or paramagnetic chelates. Memsomes also hold promise for targeting of sites outside the liver. Work is in progress to take these agents into clinical trials.

Original languageEnglish (US)
Pages (from-to)195-198
Number of pages4
JournalJournal of Magnetic Resonance Imaging
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1993

Keywords

  • Contrast enhancemen
  • Liver, MR, 761.1214
  • Manganese
  • iposomes
  • ontrast medi

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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