Steady-state theophylline pharmacokinetics during and after short-term cimetidine administration

P. M. Mulkey, J. E. Murphy, N. H. Shleifer

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Although not very toxic alone, cimetidine appears to produce interactions with certain drugs that are metabolized by the liver. 1-3 Because theophylline is metabolized by the liver and has a narrow therapeutic range, a decrease in clearance caused by interaction with cimetidine could result in unexpected accumulation of excessive amounts of theophylline and possibly lead to toxic effects.3-8 The purpose of this study was to evaluate the effects of cimetidine administration on the pharmacokinetics of theophylline at steady state and to determine if any residual effect of cimetidine persists for three days after its discontinuation.

Original languageEnglish (US)
Pages (from-to)439-441
Number of pages3
JournalClinical pharmacy
Issue number5
StatePublished - 1983
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science


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