Stenting for malignant colonic obstruction: a comparison of efficacy and complications in colonic versus extracolonic malignancy

Rajesh N. Keswani, Riad R. Azar, Steven A. Edmundowicz, Qin Zhang, Tarek Ammar, Bhaskar Banerjee, Dayna S. Early, Sreenivasa S. Jonnalagadda

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Background: Self-expandable metal stent placement for palliation of malignant colonic obstruction for colorectal cancer (CRC) is safe and efficacious. In contrast, outcomes of stent placement for extracolonic malignancy (ECM) are unclear. Objective: To compare the success and complication rates of colorectal stenting in patients with CRC versus those with ECM. Design: Retrospective chart review. Setting: Tertiary-care academic medical center. Patients and Interventions: Between September 2000 and December 2007, all patients with malignant colon obstruction in whom endoscopy was performed with the intention of placing a colonic metal stent. Main Outcome Measurements: Technical and clinical success rates, surgical interventions, and procedure-related complications. Results: Colonic stenting was performed for CRC in 34 patients and for ECM in 15 patients. Patients with CRC were more likely to have clinical success after all endoscopic therapy (94.1%) than those with ECM (20.0%) (P < .0001). Surgical diversion to relieve persistent obstructive symptoms was required in significantly more patients with ECM. Five patients with ECM (33.3%) had at least one complication, including 2 deaths, compared with 3 patients with CRC (8.8%) (P = .046). Only underlying ECM was predictive of failed colon stent placement by multivariate analysis (hazard ratio 21.0, P = .0013). A history of radiation therapy was the sole predictor of complications (hazard ratio 7.8, P = .048). Limitations: Single institution, retrospective analysis, relatively small sample size. Conclusions: Colon stenting for large-bowel obstruction from ECM is infrequently successful and is associated with a significantly higher risk of complications in comparison with patients with CRC.

Original languageEnglish (US)
Pages (from-to)675-680
Number of pages6
JournalGastrointestinal Endoscopy
Volume69
Issue number3 SUPPL.
DOIs
StatePublished - Mar 2009
Externally publishedYes

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Colorectal Neoplasms
Neoplasms
Stents
Colon
Tertiary Healthcare
Sample Size
Endoscopy
Radiotherapy
Multivariate Analysis
Metals
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Stenting for malignant colonic obstruction : a comparison of efficacy and complications in colonic versus extracolonic malignancy. / Keswani, Rajesh N.; Azar, Riad R.; Edmundowicz, Steven A.; Zhang, Qin; Ammar, Tarek; Banerjee, Bhaskar; Early, Dayna S.; Jonnalagadda, Sreenivasa S.

In: Gastrointestinal Endoscopy, Vol. 69, No. 3 SUPPL., 03.2009, p. 675-680.

Research output: Contribution to journalArticle

Keswani, Rajesh N. ; Azar, Riad R. ; Edmundowicz, Steven A. ; Zhang, Qin ; Ammar, Tarek ; Banerjee, Bhaskar ; Early, Dayna S. ; Jonnalagadda, Sreenivasa S. / Stenting for malignant colonic obstruction : a comparison of efficacy and complications in colonic versus extracolonic malignancy. In: Gastrointestinal Endoscopy. 2009 ; Vol. 69, No. 3 SUPPL. pp. 675-680.
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abstract = "Background: Self-expandable metal stent placement for palliation of malignant colonic obstruction for colorectal cancer (CRC) is safe and efficacious. In contrast, outcomes of stent placement for extracolonic malignancy (ECM) are unclear. Objective: To compare the success and complication rates of colorectal stenting in patients with CRC versus those with ECM. Design: Retrospective chart review. Setting: Tertiary-care academic medical center. Patients and Interventions: Between September 2000 and December 2007, all patients with malignant colon obstruction in whom endoscopy was performed with the intention of placing a colonic metal stent. Main Outcome Measurements: Technical and clinical success rates, surgical interventions, and procedure-related complications. Results: Colonic stenting was performed for CRC in 34 patients and for ECM in 15 patients. Patients with CRC were more likely to have clinical success after all endoscopic therapy (94.1{\%}) than those with ECM (20.0{\%}) (P < .0001). Surgical diversion to relieve persistent obstructive symptoms was required in significantly more patients with ECM. Five patients with ECM (33.3{\%}) had at least one complication, including 2 deaths, compared with 3 patients with CRC (8.8{\%}) (P = .046). Only underlying ECM was predictive of failed colon stent placement by multivariate analysis (hazard ratio 21.0, P = .0013). A history of radiation therapy was the sole predictor of complications (hazard ratio 7.8, P = .048). Limitations: Single institution, retrospective analysis, relatively small sample size. Conclusions: Colon stenting for large-bowel obstruction from ECM is infrequently successful and is associated with a significantly higher risk of complications in comparison with patients with CRC.",
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T2 - a comparison of efficacy and complications in colonic versus extracolonic malignancy

AU - Keswani, Rajesh N.

AU - Azar, Riad R.

AU - Edmundowicz, Steven A.

AU - Zhang, Qin

AU - Ammar, Tarek

AU - Banerjee, Bhaskar

AU - Early, Dayna S.

AU - Jonnalagadda, Sreenivasa S.

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N2 - Background: Self-expandable metal stent placement for palliation of malignant colonic obstruction for colorectal cancer (CRC) is safe and efficacious. In contrast, outcomes of stent placement for extracolonic malignancy (ECM) are unclear. Objective: To compare the success and complication rates of colorectal stenting in patients with CRC versus those with ECM. Design: Retrospective chart review. Setting: Tertiary-care academic medical center. Patients and Interventions: Between September 2000 and December 2007, all patients with malignant colon obstruction in whom endoscopy was performed with the intention of placing a colonic metal stent. Main Outcome Measurements: Technical and clinical success rates, surgical interventions, and procedure-related complications. Results: Colonic stenting was performed for CRC in 34 patients and for ECM in 15 patients. Patients with CRC were more likely to have clinical success after all endoscopic therapy (94.1%) than those with ECM (20.0%) (P < .0001). Surgical diversion to relieve persistent obstructive symptoms was required in significantly more patients with ECM. Five patients with ECM (33.3%) had at least one complication, including 2 deaths, compared with 3 patients with CRC (8.8%) (P = .046). Only underlying ECM was predictive of failed colon stent placement by multivariate analysis (hazard ratio 21.0, P = .0013). A history of radiation therapy was the sole predictor of complications (hazard ratio 7.8, P = .048). Limitations: Single institution, retrospective analysis, relatively small sample size. Conclusions: Colon stenting for large-bowel obstruction from ECM is infrequently successful and is associated with a significantly higher risk of complications in comparison with patients with CRC.

AB - Background: Self-expandable metal stent placement for palliation of malignant colonic obstruction for colorectal cancer (CRC) is safe and efficacious. In contrast, outcomes of stent placement for extracolonic malignancy (ECM) are unclear. Objective: To compare the success and complication rates of colorectal stenting in patients with CRC versus those with ECM. Design: Retrospective chart review. Setting: Tertiary-care academic medical center. Patients and Interventions: Between September 2000 and December 2007, all patients with malignant colon obstruction in whom endoscopy was performed with the intention of placing a colonic metal stent. Main Outcome Measurements: Technical and clinical success rates, surgical interventions, and procedure-related complications. Results: Colonic stenting was performed for CRC in 34 patients and for ECM in 15 patients. Patients with CRC were more likely to have clinical success after all endoscopic therapy (94.1%) than those with ECM (20.0%) (P < .0001). Surgical diversion to relieve persistent obstructive symptoms was required in significantly more patients with ECM. Five patients with ECM (33.3%) had at least one complication, including 2 deaths, compared with 3 patients with CRC (8.8%) (P = .046). Only underlying ECM was predictive of failed colon stent placement by multivariate analysis (hazard ratio 21.0, P = .0013). A history of radiation therapy was the sole predictor of complications (hazard ratio 7.8, P = .048). Limitations: Single institution, retrospective analysis, relatively small sample size. Conclusions: Colon stenting for large-bowel obstruction from ECM is infrequently successful and is associated with a significantly higher risk of complications in comparison with patients with CRC.

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