Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted β-turn bicyclic dipeptide mimetics

Chiyi Xiong, Junyi Zhang, Peg Davis, Wei Wang, Jinfa Ying, Frank Porreca, Victor J. Hruby

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Novel constrained β-turn dipeptide mimetics, 8-phenyl thiaindolizidinone amino acids 3, have been synthesized stereoselectively and incorporated into Leu-enkephalin peptides as a replacement of dipeptide Gly3-Phe4 to afford four individual isomers of Leu-enkephalin analogues 6.

Original languageEnglish (US)
Pages (from-to)1598-1599
Number of pages2
JournalChemical Communications
Volume3
Issue number13
DOIs
StatePublished - 2003

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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