Abstract
In this report, it is demonstrated that chiral vinyl aziridines can be stereospecifically ring expanded. This synthetic approach allows controlled access to chiral 2,5-cis-or 2,5-trans-3-pyrroline products from starting materials with the appropriate aziridine geometry. Twenty three ring expansion examples, most of which feature a stereospecific cyclization, are presented.(Figure Presented)
Original language | English (US) |
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Pages (from-to) | 1110-1113 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - Mar 4 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry