Steroid hormone activation of wandering in the isolated nervous system of Manduca sexta

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Steroid hormones modulate motor circuits in both vertebrates and invertebrates. The insect Manduca sexta, with its well-characterized developmental and endocrinological history, is a useful model system in which to study these effects. Wandering is a stage-specific locomotor behavior triggered by the steroid hormone 20-hydroxyecdysone (20E), consisting of crawling and burrowing movements as the animal searches for a pupation site. This study was undertaken to determine whether the wandering motor pattern is activated by direct action of 20E on the CNS. 20E acts on the isolated larval nervous system to induce a fictive motor pattern showing features of crawling and burrowing. The latency of the response to 20E is long, suggestive of a genomic mechanism of action. The abdominal motoneurons or segmental pattern generating circuits are unlikely to be the primary targets of 20E action in inducing fictive wandering. Exposure of the segmental ganglia alone to hormone did not evoke fictive wandering. Therefore, as suggested by an earlier study, the likely site of 20E action is within the brain.

Original languageEnglish (US)
Pages (from-to)1049-1062
Number of pages14
JournalJournal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology
Volume192
Issue number10
DOIs
StatePublished - Oct 1 2006

Keywords

  • Crawling
  • Insect
  • Locomotion
  • Pattern generation
  • Steroid hormone

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Animal Science and Zoology
  • Behavioral Neuroscience

Fingerprint Dive into the research topics of 'Steroid hormone activation of wandering in the isolated nervous system of Manduca sexta'. Together they form a unique fingerprint.

  • Cite this