Still's-like innocent murmur can be produced by increasing aortic velocity to a threshold value

Scott E Klewer, Richard L. Donnerstein, Stanley J. Goldberg

Research output: Contribution to journalArticle

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Still's murmur is a musical or vibratory systolic ejection murmur found in many normal school-aged children and adolescents. Its origin has been attributed to vibration of a cardiac structure during ventricular contraction, turbulent blood flow, or pressure changes across normal valves.1 We previously related Still's murmur to a small ascending aorta with concomitant high aortic velocity.2 Functional murmurs are accentuated in high cardiac output states such as fever, exercise and anemia. Dobutamine, a β1 agonist with primarily inotropic action at low doses, allows study of high cardiac output states. We investigated whether dobutamine infusion could produce a Stills-like murmur in subjects without murmurs at rest and evaluated those factors correlating best with murmur presence.

Original languageEnglish (US)
Pages (from-to)810-812
Number of pages3
JournalThe American journal of cardiology
Issue number8
Publication statusPublished - Sep 15 1991


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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