Stimulation by Gastric Inhibitory Polypeptide of Insulin and Glucagon Secretion by Rat Islet Cultures

Wilfred Y. Fujimoto, John W. Ensinck, Frederick W. Merchant, Robert H. Williams, Phillip H. Smith, David G. Johnson

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Physiologic amounts of GIP stimulated the secretion of IRI and IRG by monolayer cultures of neonatal rat pancreatic islets. Localization of exogenous GIP to a minority subpopulation of the islet cells was observed. The results may be interpreted to indicate that the effect of GIP on IRI release by the B cell is not direct, but rather, is mediated through its action on another islet cell type. Conversely, the action of GIP on IRG release may be directly mediated through an effect of GIP on the A cell. The action of GIP on IRG release apparently overrides any sup pressive effect that high glucose levels may exert. The stimulation by GIP of both IRI and IRG release was greater when a mixture of amino acids was omitted.

Original languageEnglish (US)
Pages (from-to)89-93
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume157
Issue number1
DOIs
StatePublished - Jan 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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