Stimulation by glucocorticoids of myoblast growth at low cell densities

Vincent Guerriero, James R. Florini

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Proliferation of rat myoblasts was stimulated by addition of 10-7 M dexamethasone to cells plated at 25 cells/cm2. In the presence of fetal calf serum and chick embryo extract, physiological levels of glucocorticoids caused a 3- to 7-fold increase in colony formation. In mass cultures, proliferation of myoblasts was also stimulated by dexamethasone, but fibroblast growth was inhibited. These opposite effects of glucocorticoids on myoblast and fibroblast growth suggest their use in cloning muscle cells from mixed cell populations.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalCell Biology International Reports
Volume2
Issue number5
DOIs
StatePublished - Sep 1978

ASJC Scopus subject areas

  • Cell Biology

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