Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen

J. C. Byatt, N. R. Staten, J. J. Schmuke, F. C. Buonomo, S. S. Galosy, D. F. Curran, G. G. Krivi, Robert J Collier

Research output: Contribution to journalArticle

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Abstract

Mature female rats (200 g) were treated for 10 days with either recombinant bovine GH (bGH) or recombinant bovine placental lactogen (bPL) to compare the somatogenic responses elicited by these hormones. The treatments were administered by daily s.c. injection at four dose levels (0.19, 0.56, l.67 and 5.0 mg/day). Both bGH and bPL stimulated significant increases in weight gain, but the slopes of the dose-response curves were different (P < 0.05). Bovine PL was more potent than bGH (P < 0.01) at the lowest dose, although there were no differences between treatment groups at the three higher doses. Feed consumption was stimulated more by bPL than bGH at all doses (P < 0.001). The concentration of insulin-like growth factor-I (IGF-I) in blood plasma was increased by bGH in a dose-responsive manner and was higher than control at doses of l.67 and 5 mg/day (P < 0.05). Fow doses of bPL stimulated increases in IGF-I similar to those with bGH. At the highest dose of bPL, however, there was no concomitant increase in plasma IGF-I. Nevertheless, the growth rate of the animals in this group matched that of the group given the highest dose of bGH. Receptor binding studies indicated that bPL bound to both GH and prolactin receptors. This is consistent with the growth data which suggest that bPL stimulated weight gain through a somatogenic mechanism as well as by another route, possibly mediated by lactogenic receptors.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalJournal of Endocrinology
Volume130
Issue number1
StatePublished - 1991
Externally publishedYes

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Placental Lactogen
Weight Gain
Body Weight
Insulin-Like Growth Factor I
Prolactin Receptors
Growth

ASJC Scopus subject areas

  • Endocrinology

Cite this

Byatt, J. C., Staten, N. R., Schmuke, J. J., Buonomo, F. C., Galosy, S. S., Curran, D. F., ... Collier, R. J. (1991). Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen. Journal of Endocrinology, 130(1), 11-19.

Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen. / Byatt, J. C.; Staten, N. R.; Schmuke, J. J.; Buonomo, F. C.; Galosy, S. S.; Curran, D. F.; Krivi, G. G.; Collier, Robert J.

In: Journal of Endocrinology, Vol. 130, No. 1, 1991, p. 11-19.

Research output: Contribution to journalArticle

Byatt, JC, Staten, NR, Schmuke, JJ, Buonomo, FC, Galosy, SS, Curran, DF, Krivi, GG & Collier, RJ 1991, 'Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen', Journal of Endocrinology, vol. 130, no. 1, pp. 11-19.
Byatt JC, Staten NR, Schmuke JJ, Buonomo FC, Galosy SS, Curran DF et al. Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen. Journal of Endocrinology. 1991;130(1):11-19.
Byatt, J. C. ; Staten, N. R. ; Schmuke, J. J. ; Buonomo, F. C. ; Galosy, S. S. ; Curran, D. F. ; Krivi, G. G. ; Collier, Robert J. / Stimulation of body weight gain of the mature female rat by bovine GH and bovine placental lactogen. In: Journal of Endocrinology. 1991 ; Vol. 130, No. 1. pp. 11-19.
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abstract = "Mature female rats (200 g) were treated for 10 days with either recombinant bovine GH (bGH) or recombinant bovine placental lactogen (bPL) to compare the somatogenic responses elicited by these hormones. The treatments were administered by daily s.c. injection at four dose levels (0.19, 0.56, l.67 and 5.0 mg/day). Both bGH and bPL stimulated significant increases in weight gain, but the slopes of the dose-response curves were different (P < 0.05). Bovine PL was more potent than bGH (P < 0.01) at the lowest dose, although there were no differences between treatment groups at the three higher doses. Feed consumption was stimulated more by bPL than bGH at all doses (P < 0.001). The concentration of insulin-like growth factor-I (IGF-I) in blood plasma was increased by bGH in a dose-responsive manner and was higher than control at doses of l.67 and 5 mg/day (P < 0.05). Fow doses of bPL stimulated increases in IGF-I similar to those with bGH. At the highest dose of bPL, however, there was no concomitant increase in plasma IGF-I. Nevertheless, the growth rate of the animals in this group matched that of the group given the highest dose of bGH. Receptor binding studies indicated that bPL bound to both GH and prolactin receptors. This is consistent with the growth data which suggest that bPL stimulated weight gain through a somatogenic mechanism as well as by another route, possibly mediated by lactogenic receptors.",
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