Stimulation of insulin-like growth factor-I production by recombinant bovine growth hormone in Mozambique tilapia, Oreochromis mossambicus

S. Kajimura, K. Uchida, T. Yada, L. G. Riley, J. C. Byatt, R. J. Collier, K. Aida, T. Hirano, E. G. Grau

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

We have previously reported growth-promoting effects of recombinant bovine growth hormone (rbGH) in Mozambique tilapia, Oreochromis mossambicus, after 4 weekly injections or a single injection of slow-releasing formulation (Posilac®) (Leedom et al. 2002). In order to obtain further understanding of the role of the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis in growth in the tilapia, the effects of rbGH on plasma and mRNA levels of IGF-I were examined. Plasma IGF-I levels were significantly increased after rbGH and Posilac® injections, and a significant correlation was observed between plasma IGF-I levels, body length and mass in both treatments. IGF-I mRNA levels in the liver and in the skeletal muscle were also significantly increased after rbGH and Posilac® injections, indicating that IGF-I gene expression in these tissues is under control of circulating GH. IGF-I mRNA levels in the gill were not affected by treatment. Liver IGF-I mRNA levels were significantly correlated with body length and with body mass after rbGH and Posilac® injections. These results indicate that the growth-promoting effect of rbGH in this species is mediated to a significant extent via its stimulation of hepatic production of IGF-I and the resulting increase in plasma IGF-I, and also possibly through locally produced IGF-I in the skeletal muscle, acting in a paracrine or autocrine fashion.

Original languageEnglish (US)
Pages (from-to)221-230
Number of pages10
JournalFish Physiology and Biochemistry
Volume25
Issue number3
DOIs
StatePublished - Dec 2001

Keywords

  • Growth hormone
  • Insulin-like growth factor-I
  • Oreochromis mossambicus
  • RNase protection assay
  • Tilapia

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Aquatic Science

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