Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin

Nafees Ahmad, Shubh D. Sharma, Anil K. Rastogi, Jalil R. Kidwai, Krishna B. Mathur

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10-8 M and 10-6 M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalActa Diabetologica Latina
Volume21
Issue number4
DOIs
StatePublished - Oct 1 1984
Externally publishedYes

Keywords

  • C-terminal tetrapeptide amide
  • Cholecystokinin
  • Insulin secretion
  • Islets of Langerhans
  • Synthetic analogue

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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