Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin

Nafees - Ahmad, Shubh D. Sharma, Anil K. Rastogi, Jalil R. Kidwai, Krishna B. Mathur

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10-8 M and 10-6 M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.

Original languageEnglish (US)
Pages (from-to)361-364
Number of pages4
JournalActa Diabetologica Latina
Volume21
Issue number4
DOIs
StatePublished - Oct 1984
Externally publishedYes

Fingerprint

Tetragastrin
Amides
Insulin
Peptides
Islets of Langerhans
Pancreas

Keywords

  • C-terminal tetrapeptide amide
  • Cholecystokinin
  • Insulin secretion
  • Islets of Langerhans
  • Synthetic analogue

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin. / Ahmad, Nafees -; Sharma, Shubh D.; Rastogi, Anil K.; Kidwai, Jalil R.; Mathur, Krishna B.

In: Acta Diabetologica Latina, Vol. 21, No. 4, 10.1984, p. 361-364.

Research output: Contribution to journalArticle

Ahmad, Nafees - ; Sharma, Shubh D. ; Rastogi, Anil K. ; Kidwai, Jalil R. ; Mathur, Krishna B. / Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin. In: Acta Diabetologica Latina. 1984 ; Vol. 21, No. 4. pp. 361-364.
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