Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow.

J. C. Byatt, P. J. Eppard, L. Munyakazi, R. H. Sorbet, J. J. Veenhuizen, D. F. Curran, Robert J Collier

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A 6 x 6 Latin square design was used to test the effects of recombinant bovine placental lactogen on milk yield, milk composition, feed intake, and blood hormone and metabolite levels in nonpregnant lactating cows. The six treatments (5, 10, 20, and 40 mg/d of placental lactogen, water as negative control, and 20 mg/d of bST as positive control) were administered by subcutaneous injection twice daily for 9 d. Blood samples were taken during the last 5 d of the treatment period. The three highest doses of placental lactogen increased milk yield, and there was a linear dose effect, although placental lactogen was less potent than bST. Milk concentrations of lactose, protein, and fat were not altered by any of the treatments. Dry matter intake was increased by two of the doses of placental lactogen, but not by bST. Blood urea N concentration was decreased in a dose-dependent manner by placental lactogen and was also decreased by bST. Similarly, serum insulin-like growth factor-I was increased in a dose-dependent manner by placental lactogen and was also increased by bST. Plasma concentrations of NEFA and glucose were increased by bST, but placental lactogen had little or no effect on either of these parameters. Thus, placental lactogen appears to act, in part, as a weak somatotropin agonist; however, it also appears to have specific activities, e.g., stimulating feed intake.

Original languageEnglish (US)
Pages (from-to)1216-1223
Number of pages8
JournalJournal of Dairy Science
Volume75
Issue number5
StatePublished - May 1992
Externally publishedYes

Fingerprint

choriomammotropin
Placental Lactogen
milk yield
Milk
dairy cows
feed intake
cattle
dosage
blood
subcutaneous injection
Subcutaneous Injections
Lactose
insulin-like growth factor I
blood serum
milk composition
Insulin-Like Growth Factor I
Nonesterified Fatty Acids
somatotropin
dry matter intake
Growth Hormone

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)

Cite this

Byatt, J. C., Eppard, P. J., Munyakazi, L., Sorbet, R. H., Veenhuizen, J. J., Curran, D. F., & Collier, R. J. (1992). Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow. Journal of Dairy Science, 75(5), 1216-1223.

Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow. / Byatt, J. C.; Eppard, P. J.; Munyakazi, L.; Sorbet, R. H.; Veenhuizen, J. J.; Curran, D. F.; Collier, Robert J.

In: Journal of Dairy Science, Vol. 75, No. 5, 05.1992, p. 1216-1223.

Research output: Contribution to journalArticle

Byatt, JC, Eppard, PJ, Munyakazi, L, Sorbet, RH, Veenhuizen, JJ, Curran, DF & Collier, RJ 1992, 'Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow.', Journal of Dairy Science, vol. 75, no. 5, pp. 1216-1223.
Byatt JC, Eppard PJ, Munyakazi L, Sorbet RH, Veenhuizen JJ, Curran DF et al. Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow. Journal of Dairy Science. 1992 May;75(5):1216-1223.
Byatt, J. C. ; Eppard, P. J. ; Munyakazi, L. ; Sorbet, R. H. ; Veenhuizen, J. J. ; Curran, D. F. ; Collier, Robert J. / Stimulation of milk yield and feed intake by bovine placental lactogen in the dairy cow. In: Journal of Dairy Science. 1992 ; Vol. 75, No. 5. pp. 1216-1223.
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