Stimulation of Rat Bladder Epithelial DNA Synthesis by Intravesical Instillation of Distilled Water

Seiichiro Ozono, Ryoichi Oyasu, in Chul Lee, Ronald S. Weinstein

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Two commonly used cystoscopic infusion fluids were examined to determine whether their infusion stimulates DNA synthesis of the bladder epithelium. Following a single intravesical dose of 0.5 ml of distilled water or 1.5% L-glycine solution, rats were killed periodically up to 1 week. A transient but significant increase in epithelial cell [3H]thymidine labeling was observed at 48 hr after distilled water instillation. Glycine solution did not stimulate DNA synthesis.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume182
Issue number3
DOIs
StatePublished - Jul 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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