Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

A. L. Spieles-Engemann, M. M. Behbehani, T. J. Collier, S. L. Wohlgenant, K. Steece-Collier, K. Paumier, B. F. Daley, S. Gombash, Lalitha Madhavan, G. T. Mandybur, J. W. Lipton, B. T. Terpstra, C. E. Sortwell

Research output: Contribution to journalArticle

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Abstract

Deep brain stimulation of the subthalamic nucleus (STN-DBS) is efficacious in treating the motor symptoms of Parkinson's disease (PD). However, the impact of STN-DBS on the progression of PD is unknown. Previous preclinical studies have demonstrated that STN-DBS can attenuate the degeneration of a relatively intact nigrostriatal system from dopamine (DA)-depleting neurotoxins. The present study examined whether STN-DBS can provide neuroprotection in the face of prior significant nigral DA neuron loss similar to PD patients at the time of diagnosis. STN-DBS between 2 and 4. weeks after intrastriatal 6-hydroxydopamine (6-OHDA) provided significant sparing of DA neurons in the SN of rats. This effect was not due to inadvertent lesioning of the STN and was dependent upon proper electrode placement. Since STN-DBS appears to have significant neuroprotective properties, initiation of STN-DBS earlier in the course of PD may provide added neuroprotective benefits in addition to its ability to provide symptomatic relief.

Original languageEnglish (US)
Pages (from-to)105-115
Number of pages11
JournalNeurobiology of Disease
Volume39
Issue number1
DOIs
StatePublished - Jul 2010
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Dopaminergic Neurons
Substantia Nigra
Parkinson Disease
Oxidopamine
Deep Brain Stimulation
Neurotoxins
Dopamine
Electrodes

Keywords

  • 6-hydroxydopamine
  • Deep brain stimulation
  • Neuroprotection
  • Parkinson's disease
  • Stereology
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neurology

Cite this

Spieles-Engemann, A. L., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Steece-Collier, K., Paumier, K., ... Sortwell, C. E. (2010). Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiology of Disease, 39(1), 105-115. https://doi.org/10.1016/j.nbd.2010.03.009

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. / Spieles-Engemann, A. L.; Behbehani, M. M.; Collier, T. J.; Wohlgenant, S. L.; Steece-Collier, K.; Paumier, K.; Daley, B. F.; Gombash, S.; Madhavan, Lalitha; Mandybur, G. T.; Lipton, J. W.; Terpstra, B. T.; Sortwell, C. E.

In: Neurobiology of Disease, Vol. 39, No. 1, 07.2010, p. 105-115.

Research output: Contribution to journalArticle

Spieles-Engemann, AL, Behbehani, MM, Collier, TJ, Wohlgenant, SL, Steece-Collier, K, Paumier, K, Daley, BF, Gombash, S, Madhavan, L, Mandybur, GT, Lipton, JW, Terpstra, BT & Sortwell, CE 2010, 'Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss', Neurobiology of Disease, vol. 39, no. 1, pp. 105-115. https://doi.org/10.1016/j.nbd.2010.03.009
Spieles-Engemann AL, Behbehani MM, Collier TJ, Wohlgenant SL, Steece-Collier K, Paumier K et al. Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiology of Disease. 2010 Jul;39(1):105-115. https://doi.org/10.1016/j.nbd.2010.03.009
Spieles-Engemann, A. L. ; Behbehani, M. M. ; Collier, T. J. ; Wohlgenant, S. L. ; Steece-Collier, K. ; Paumier, K. ; Daley, B. F. ; Gombash, S. ; Madhavan, Lalitha ; Mandybur, G. T. ; Lipton, J. W. ; Terpstra, B. T. ; Sortwell, C. E. / Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. In: Neurobiology of Disease. 2010 ; Vol. 39, No. 1. pp. 105-115.
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