Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system

Ella M Nikulina, Violetta Klimek

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The influence of a genotype of inbred mice on the aggressive behavior induced by clonidine and the role of dopamine D1 and D2 receptors in that behavior were studied. Clonidine in a dose of 10 mg/kg evoked a strong aggressiveness in BALB/c, DBA/1, and CC57Br mice and an intermediate response in C57BL/6J, Albino Swiss, and CBA mice, whereas DD, A/He, and C3HA/y mice did not show any aggressive behavior. Apomorphine significantly potentiated the clonidine-induced aggressiveness in C57BL/6J mice. In Albino Swiss mice, SK&F38393 as well as quinpirole augmented the aggressive behavior evoked by clonidine. The clonidine-induced aggressiveness was blocked by SCH23390 and cis-flupentixol but not by (-)-sulpiride. In aggressive mice, the binding of [3H]SCH23390 was decreased in the limbic forebrain, whereas the binding of [3H]spiperone was not changed. The obtained results indicate that the potency of the clonidine-induced aggressiveness depends upon genotype of mice; moreover, the presence of a physiological function of D1 receptors is necessary for its occurrence.

Original languageEnglish (US)
Pages (from-to)821-825
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume44
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Clonidine
Dopamine
Flupenthixol
Quinpirole
Spiperone
Genotype
Dopamine D1 Receptors
Sulpiride
Dopamine D2 Receptors
Apomorphine
Inbred CBA Mouse
Prosencephalon
Inbred C57BL Mouse

Keywords

  • Aggression
  • Clonidine
  • Dopamine receptors
  • Genotype

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system. / Nikulina, Ella M; Klimek, Violetta.

In: Pharmacology, Biochemistry and Behavior, Vol. 44, No. 4, 1993, p. 821-825.

Research output: Contribution to journalArticle

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