Strategies for cyclizations of novel peptides on solid supports

Victor J. Hruby, Susanne Wilke, Fahad Al-Obeidi, Ding Jiao, Ying Lin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Synthetic strategies and methods for the preparation of cyclic peptides on solid supports are very important for peptide synthesis in general, and for the preparation of conformationally constrained biologically active peptides. In this paper we report synthetic methods for the preparation on solid supports of the cyclic and bicyclic biologically active peptides, Ac-[Nle4, Asp5, d-Phe, Lys10]α-melanotropin(4-10)-NH2, [Lys17, Lys18, Asp21]glucagon-NH2, [β-Mpa1, Glu4, Cys6, Lys8]oxytocin and cyclo[GlyTrpNMeNleAspPhe] (cyclic CCK-5 analogue).

Original languageEnglish (US)
Pages (from-to)231-241
Number of pages11
JournalReactive Polymers
Volume22
Issue number3
DOIs
StatePublished - Jun 1994

Keywords

  • Cyclic disulfides
  • Cyclic lactams
  • Cyclic peptides
  • Cyclization of solid supports
  • Cyclization on solid supports
  • Orthogonal synthesis
  • Solid-phase synthesis

ASJC Scopus subject areas

  • Engineering(all)

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