Strategies of obligate intracellular parasites for evading host defences

B. Fenton Hall, Keith A Joiner

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.

Original languageEnglish (US)
JournalImmunology Today
Volume12
Issue number3
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Parasites
Poisons
Trypanosoma cruzi
Leishmania
Toxoplasma
Hydrolases
Oxygen
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Strategies of obligate intracellular parasites for evading host defences. / Hall, B. Fenton; Joiner, Keith A.

In: Immunology Today, Vol. 12, No. 3, 1991.

Research output: Contribution to journalArticle

@article{18172f5083954523a9c678e920dce534,
title = "Strategies of obligate intracellular parasites for evading host defences",
abstract = "During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.",
author = "Hall, {B. Fenton} and Joiner, {Keith A}",
year = "1991",
doi = "10.1016/S0167-5699(05)80007-6",
language = "English (US)",
volume = "12",
journal = "Trends in Immunology",
issn = "1471-4906",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Strategies of obligate intracellular parasites for evading host defences

AU - Hall, B. Fenton

AU - Joiner, Keith A

PY - 1991

Y1 - 1991

N2 - During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.

AB - During the course of establishing infection in a susceptible host, obligate intracellular parasites evade host defence mechanisms before, during and after entry into host cells. Before entry they circumvent the lytic activity of the complement cascade, during cell entry they avoid being killed by toxic oxygen metabolites and after entry they escape nonoxidative killing mechanisms such as degradation by lysosomal hydrolases. Different intracellular parasites, exemplified here by Leishmania spp, Trypanosoma cruzi and Toxoplasma gondii, undermine host defences at each step by various strategies that ultimately ensure their targeting to, and survival in, an appropriate intracellular compartment.

UR - http://www.scopus.com/inward/record.url?scp=0025833615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025833615&partnerID=8YFLogxK

U2 - 10.1016/S0167-5699(05)80007-6

DO - 10.1016/S0167-5699(05)80007-6

M3 - Article

C2 - 2069674

AN - SCOPUS:0025833615

VL - 12

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 3

ER -