Stress granules and ALS: A case of causation or correlation?

Nikita Fernandes, Nichole Eshleman, John R Buchan

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.

Original languageEnglish (US)
Title of host publicationAdvances in Neurobiology
PublisherSpringer New York LLC
Pages173-212
Number of pages40
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Neurobiology
Volume20
ISSN (Print)2190-5215

Fingerprint

Amyotrophic Lateral Sclerosis
Causality
Neurodegenerative diseases
Pathology
Neurons
Motor Neurons
Neurodegenerative Diseases
Protein Aggregates

Keywords

  • ALS
  • Autophagy
  • C9ORF72
  • Chaperones
  • Cytoskeleton
  • FUS
  • mRNA
  • SOD1
  • Stress granules
  • TDP-43

ASJC Scopus subject areas

  • Biochemistry
  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Fernandes, N., Eshleman, N., & Buchan, J. R. (2018). Stress granules and ALS: A case of causation or correlation? In Advances in Neurobiology (pp. 173-212). (Advances in Neurobiology; Vol. 20). Springer New York LLC. https://doi.org/10.1007/978-3-319-89689-2_7

Stress granules and ALS : A case of causation or correlation? / Fernandes, Nikita; Eshleman, Nichole; Buchan, John R.

Advances in Neurobiology. Springer New York LLC, 2018. p. 173-212 (Advances in Neurobiology; Vol. 20).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fernandes, N, Eshleman, N & Buchan, JR 2018, Stress granules and ALS: A case of causation or correlation? in Advances in Neurobiology. Advances in Neurobiology, vol. 20, Springer New York LLC, pp. 173-212. https://doi.org/10.1007/978-3-319-89689-2_7
Fernandes N, Eshleman N, Buchan JR. Stress granules and ALS: A case of causation or correlation? In Advances in Neurobiology. Springer New York LLC. 2018. p. 173-212. (Advances in Neurobiology). https://doi.org/10.1007/978-3-319-89689-2_7
Fernandes, Nikita ; Eshleman, Nichole ; Buchan, John R. / Stress granules and ALS : A case of causation or correlation?. Advances in Neurobiology. Springer New York LLC, 2018. pp. 173-212 (Advances in Neurobiology).
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