Stroke

Development, prevention and treatment with peptidase inhibitors

K. S. Mark, Thomas P Davis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.

Original languageEnglish (US)
Pages (from-to)1965-1973
Number of pages9
JournalPeptides
Volume22
Issue number12
StatePublished - 2001

Fingerprint

Protease Inhibitors
Angiotensin-Converting Enzyme Inhibitors
Stroke
Antihypertensive Agents
Hypertension
Mortality
Nervous System Diseases
Morbidity

Keywords

  • ACE inhibitors
  • Cellular mechanisms
  • Hypertension
  • Hypoxia/reoxygenation
  • Stroke

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Stroke : Development, prevention and treatment with peptidase inhibitors. / Mark, K. S.; Davis, Thomas P.

In: Peptides, Vol. 22, No. 12, 2001, p. 1965-1973.

Research output: Contribution to journalArticle

@article{e111453055424384a3017439ad374293,
title = "Stroke: Development, prevention and treatment with peptidase inhibitors",
abstract = "Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.",
keywords = "ACE inhibitors, Cellular mechanisms, Hypertension, Hypoxia/reoxygenation, Stroke",
author = "Mark, {K. S.} and Davis, {Thomas P}",
year = "2001",
language = "English (US)",
volume = "22",
pages = "1965--1973",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "12",

}

TY - JOUR

T1 - Stroke

T2 - Development, prevention and treatment with peptidase inhibitors

AU - Mark, K. S.

AU - Davis, Thomas P

PY - 2001

Y1 - 2001

N2 - Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.

AB - Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.

KW - ACE inhibitors

KW - Cellular mechanisms

KW - Hypertension

KW - Hypoxia/reoxygenation

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0034860468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034860468&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 1965

EP - 1973

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 12

ER -