Abstract
Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1965-1973 |
| Number of pages | 9 |
| Journal | Peptides |
| Volume | 21 |
| Issue number | 12 |
| DOIs | |
| State | Published - 2000 |
Fingerprint
Keywords
- ACE inhibitors
- Cellular mechanisms
- Hypertension
- Hypoxia/reoxygenation
- Stroke
ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
- Cellular and Molecular Neuroscience
Cite this
Stroke : Development, prevention and treatment with peptidase inhibitors. / Mark, Karen S.; Davis, Thomas P.
In: Peptides, Vol. 21, No. 12, 2000, p. 1965-1973.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stroke
T2 - Development, prevention and treatment with peptidase inhibitors
AU - Mark, Karen S.
AU - Davis, Thomas P
PY - 2000
Y1 - 2000
N2 - Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.
AB - Stroke is the leading cause of long-term disability in the United States and affects more people than any other neurologic disorder. Hypertension is a major risk factor associated with stroke. Several anti-hypertensive agents have been used to treat chronic hypertension to reduce the morbidity and mortality of stroke. Previous experimental studies have shown reduced stroke mortality with angiotensin-converting enzyme (ACE) inhibitors. This review discusses the development of stroke and potential use of ACE inhibitors in prevention and treatment of this disease. Furthermore, this review focuses on current investigations aimed at cellular mechanisms involved in stroke-induced microvascular alterations.
KW - ACE inhibitors
KW - Cellular mechanisms
KW - Hypertension
KW - Hypoxia/reoxygenation
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=0034528312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034528312&partnerID=8YFLogxK
U2 - 10.1016/S0196-9781(00)00346-6
DO - 10.1016/S0196-9781(00)00346-6
M3 - Article
C2 - 11150655
VL - 21
SP - 1965
EP - 1973
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 12
ER -