Structural response of microcirculatory networks to changes in demand: Information transfer by shear stress

A. R. Pries, B. Reglin, Timothy W Secomb

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Matching blood flow to metabolic demand in terminal vascular beds involves coordinated changes in diameters of vessels along flow pathways, requiring upstream and downstream transfer of information on local conditions. Here, the role of information transfer mechanisms in structural adaptation of microvascular networks after a small change in capillary oxygen demand was studied using a theoretical model. The model includes diameter adaptation and information transfer via vascular reactions to wall shear stress, transmural pressure, and oxygen levels. Information transfer is additionally effected by conduction along vessel walls and by convection of metabolites. The model permits selective blocking of information transfer mechanisms. Six networks, based on in vivo data, were considered. With information transfer, increases in network conductance and capillary oxygen supply were amplified by factors of 4.9 ± 0.2 and 9.4 ± 1.1 (means ± SE), relative to increases when information transfer was blocked. Information transfer by flow coupling alone, in which increased shear stress triggers vascular enlargement, gave amplifications of 4.0 ± 0.3 and 4.9 ± 0.5. Other information transfer mechanisms acting alone gave amplifications below 1.6. Thus shear-stress-mediated flow coupling is the main mechanism for the structural adjustment of feeding and draining vessel diameters to small changes in capillary oxygen demand.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume284
Issue number6 53-6
StatePublished - Jun 1 2003

Fingerprint

Oxygen
Blood Vessels
Convection
Microvessels
Theoretical Models
Pressure

Keywords

  • Blood flow
  • Blood pressure
  • Hemodynamics
  • Model simulation
  • Vascular adaptation

ASJC Scopus subject areas

  • Physiology

Cite this

@article{d6323992f3db4d2c8a688f5048587782,
title = "Structural response of microcirculatory networks to changes in demand: Information transfer by shear stress",
abstract = "Matching blood flow to metabolic demand in terminal vascular beds involves coordinated changes in diameters of vessels along flow pathways, requiring upstream and downstream transfer of information on local conditions. Here, the role of information transfer mechanisms in structural adaptation of microvascular networks after a small change in capillary oxygen demand was studied using a theoretical model. The model includes diameter adaptation and information transfer via vascular reactions to wall shear stress, transmural pressure, and oxygen levels. Information transfer is additionally effected by conduction along vessel walls and by convection of metabolites. The model permits selective blocking of information transfer mechanisms. Six networks, based on in vivo data, were considered. With information transfer, increases in network conductance and capillary oxygen supply were amplified by factors of 4.9 ± 0.2 and 9.4 ± 1.1 (means ± SE), relative to increases when information transfer was blocked. Information transfer by flow coupling alone, in which increased shear stress triggers vascular enlargement, gave amplifications of 4.0 ± 0.3 and 4.9 ± 0.5. Other information transfer mechanisms acting alone gave amplifications below 1.6. Thus shear-stress-mediated flow coupling is the main mechanism for the structural adjustment of feeding and draining vessel diameters to small changes in capillary oxygen demand.",
keywords = "Blood flow, Blood pressure, Hemodynamics, Model simulation, Vascular adaptation",
author = "Pries, {A. R.} and B. Reglin and Secomb, {Timothy W}",
year = "2003",
month = "6",
day = "1",
language = "English (US)",
volume = "284",
journal = "American Journal of Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "6 53-6",

}

TY - JOUR

T1 - Structural response of microcirculatory networks to changes in demand

T2 - Information transfer by shear stress

AU - Pries, A. R.

AU - Reglin, B.

AU - Secomb, Timothy W

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Matching blood flow to metabolic demand in terminal vascular beds involves coordinated changes in diameters of vessels along flow pathways, requiring upstream and downstream transfer of information on local conditions. Here, the role of information transfer mechanisms in structural adaptation of microvascular networks after a small change in capillary oxygen demand was studied using a theoretical model. The model includes diameter adaptation and information transfer via vascular reactions to wall shear stress, transmural pressure, and oxygen levels. Information transfer is additionally effected by conduction along vessel walls and by convection of metabolites. The model permits selective blocking of information transfer mechanisms. Six networks, based on in vivo data, were considered. With information transfer, increases in network conductance and capillary oxygen supply were amplified by factors of 4.9 ± 0.2 and 9.4 ± 1.1 (means ± SE), relative to increases when information transfer was blocked. Information transfer by flow coupling alone, in which increased shear stress triggers vascular enlargement, gave amplifications of 4.0 ± 0.3 and 4.9 ± 0.5. Other information transfer mechanisms acting alone gave amplifications below 1.6. Thus shear-stress-mediated flow coupling is the main mechanism for the structural adjustment of feeding and draining vessel diameters to small changes in capillary oxygen demand.

AB - Matching blood flow to metabolic demand in terminal vascular beds involves coordinated changes in diameters of vessels along flow pathways, requiring upstream and downstream transfer of information on local conditions. Here, the role of information transfer mechanisms in structural adaptation of microvascular networks after a small change in capillary oxygen demand was studied using a theoretical model. The model includes diameter adaptation and information transfer via vascular reactions to wall shear stress, transmural pressure, and oxygen levels. Information transfer is additionally effected by conduction along vessel walls and by convection of metabolites. The model permits selective blocking of information transfer mechanisms. Six networks, based on in vivo data, were considered. With information transfer, increases in network conductance and capillary oxygen supply were amplified by factors of 4.9 ± 0.2 and 9.4 ± 1.1 (means ± SE), relative to increases when information transfer was blocked. Information transfer by flow coupling alone, in which increased shear stress triggers vascular enlargement, gave amplifications of 4.0 ± 0.3 and 4.9 ± 0.5. Other information transfer mechanisms acting alone gave amplifications below 1.6. Thus shear-stress-mediated flow coupling is the main mechanism for the structural adjustment of feeding and draining vessel diameters to small changes in capillary oxygen demand.

KW - Blood flow

KW - Blood pressure

KW - Hemodynamics

KW - Model simulation

KW - Vascular adaptation

UR - http://www.scopus.com/inward/record.url?scp=0038104888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038104888&partnerID=8YFLogxK

M3 - Article

C2 - 12573998

AN - SCOPUS:0038104888

VL - 284

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6143

IS - 6 53-6

ER -