Structure and function of a transcriptional network activated by the MAPK Hog1

Andrew P Capaldi, Tommy Kaplan, Ying Liu, Naomi Habib, Aviv Regev, Nir Friedman, Erin K. O’shea

Research output: Contribution to journalArticle

149 Scopus citations

Abstract

Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. To gain insight into the structure and function of these networks, we analyzed gene expression in single- and multiple-mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast. Our model reveals that the Hog1 and general stress (Msn2/4) pathways interact, at both the signaling and promoter level, to integrate information and create a context-dependent response. This study lays out a path to identifying and characterizing the role of signal integration and processing in other gene regulatory networks.

Original languageEnglish (US)
Pages (from-to)1300-1306
Number of pages7
JournalNature Genetics
Volume40
Issue number11
DOIs
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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    Capaldi, A. P., Kaplan, T., Liu, Y., Habib, N., Regev, A., Friedman, N., & O’shea, E. K. (2008). Structure and function of a transcriptional network activated by the MAPK Hog1. Nature Genetics, 40(11), 1300-1306. https://doi.org/10.1038/ng.235