Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.

A. Rosenthal, L. Rhee, R. Yadegari, R. Paro, A. Ullrich, D. V. Goeddel

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Abstract

Genomic and cDNA clones encoding a Drosophila melanogaster protein kinase C (PKC) homologue were identified using a bovine PKC cDNA probe. The cDNA clones contain a single open reading frame that encodes a 639 amino acid, 75-kd protein having extensive homology with bovine, human and rat PKC and homology with the kinase domains of other serine, threonine and tyrosine kinases. The Drosophila PKC gene is localized to region 53E of chromosome 2. The gene spans approximately 20 kb and contains at least 14 exons. Messenger RNA for PKC could not be detected in 0-3 h Drosophila embryos. Adult flies contain three PKC transcripts of 4.3, 4.0 and 2.4 kb.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalEMBO Journal
Volume6
Issue number2
StatePublished - Feb 1 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Rosenthal, A., Rhee, L., Yadegari, R., Paro, R., Ullrich, A., & Goeddel, D. V. (1987). Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO Journal, 6(2), 433-441.