Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.

A. Rosenthal, L. Rhee, Ramin Yadegari, R. Paro, A. Ullrich, D. V. Goeddel

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Genomic and cDNA clones encoding a Drosophila melanogaster protein kinase C (PKC) homologue were identified using a bovine PKC cDNA probe. The cDNA clones contain a single open reading frame that encodes a 639 amino acid, 75-kd protein having extensive homology with bovine, human and rat PKC and homology with the kinase domains of other serine, threonine and tyrosine kinases. The Drosophila PKC gene is localized to region 53E of chromosome 2. The gene spans approximately 20 kb and contains at least 14 exons. Messenger RNA for PKC could not be detected in 0-3 h Drosophila embryos. Adult flies contain three PKC transcripts of 4.3, 4.0 and 2.4 kb.

Original languageEnglish (US)
Pages (from-to)433-441
Number of pages9
JournalEMBO Journal
Volume6
Issue number2
StatePublished - Feb 1987
Externally publishedYes

Fingerprint

Drosophila Proteins
Protein Kinase C
Nucleotides
Genes
Complementary DNA
Clone Cells
Chromosomes, Human, Pair 2
Protein-Serine-Threonine Kinases
Chromosomes
Diptera
Protein-Tyrosine Kinases
Open Reading Frames
Drosophila
Rats
Exons
Phosphotransferases
Embryonic Structures
Amino Acids
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Rosenthal, A., Rhee, L., Yadegari, R., Paro, R., Ullrich, A., & Goeddel, D. V. (1987). Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO Journal, 6(2), 433-441.

Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. / Rosenthal, A.; Rhee, L.; Yadegari, Ramin; Paro, R.; Ullrich, A.; Goeddel, D. V.

In: EMBO Journal, Vol. 6, No. 2, 02.1987, p. 433-441.

Research output: Contribution to journalArticle

Rosenthal, A, Rhee, L, Yadegari, R, Paro, R, Ullrich, A & Goeddel, DV 1987, 'Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene.', EMBO Journal, vol. 6, no. 2, pp. 433-441.
Rosenthal A, Rhee L, Yadegari R, Paro R, Ullrich A, Goeddel DV. Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. EMBO Journal. 1987 Feb;6(2):433-441.
Rosenthal, A. ; Rhee, L. ; Yadegari, Ramin ; Paro, R. ; Ullrich, A. ; Goeddel, D. V. / Structure and nucleotide sequence of a Drosophila melanogaster protein kinase C gene. In: EMBO Journal. 1987 ; Vol. 6, No. 2. pp. 433-441.
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