Structure of a two-G-tetrad intramolecular G-quadruplex formed by variant human telomeric sequence in K+ solution: Insights into the interconversion of human telomeric G-quadruplex structures

Zhenjiang Zhang, Jixun Dai, Elizabeth Veliath, Roger A. Jones, Danzhou Yang

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K+ solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5′-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.

Original languageEnglish (US)
Article numbergkp1029
Pages (from-to)1009-1021
Number of pages13
JournalNucleic acids research
Volume38
Issue number3
DOIs
StatePublished - Nov 27 2009

ASJC Scopus subject areas

  • Genetics

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