Structure of a two-G-tetrad intramolecular G-quadruplex formed by variant human telomeric sequence in K+ solution: Insights into the interconversion of human telomeric G-quadruplex structures

Zhenjiang Zhang, Jixun Dai, Elizabeth Veliath, Roger A. Jones, Danzhou Yang

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K+ solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5′-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.

Original languageEnglish (US)
Article numbergkp1029
Pages (from-to)1009-1021
Number of pages13
JournalNucleic Acids Research
Volume38
Issue number3
DOIs
StatePublished - Nov 27 2009

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G-Quadruplexes
Neoplasms

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  • Genetics

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Structure of a two-G-tetrad intramolecular G-quadruplex formed by variant human telomeric sequence in K+ solution : Insights into the interconversion of human telomeric G-quadruplex structures. / Zhang, Zhenjiang; Dai, Jixun; Veliath, Elizabeth; Jones, Roger A.; Yang, Danzhou.

In: Nucleic Acids Research, Vol. 38, No. 3, gkp1029, 27.11.2009, p. 1009-1021.

Research output: Contribution to journalArticle

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