Studies in vivo with dynorphin-(1-9): Analgesia but not gastrointestinal effects following intrathecal administration to mice

Frank Porreca, Alessandro Filla, Thomas F. Burks

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Direct administration of dynorphin-(1-9) (10-100 μg) into the spinal subarachnoid space of mice produced a dose-related analgesic effect at 5 and 10, but not 35 min, in the tail-flick test using hot water as the nociceptive stimulus. By contrast, the same doses did not affect gastrointestinal transit at 5, 10, 15 or 35 min after injection. These results suggest that dynorphin-(1-9) is similar in this endpoint to ketazocine-type κ opioid agonists in naive animals while confirming that intrathecal administration of dynorphin is analgesic in mice.

Original languageEnglish (US)
Pages (from-to)291-294
Number of pages4
JournalEuropean Journal of Pharmacology
Volume91
Issue number2-3
DOIs
StatePublished - Jul 22 1983
Externally publishedYes

Keywords

  • Analgesia
  • Dynorphin-(1-9)
  • Gastrointestinal transit
  • Intrathecal administration
  • Mice

ASJC Scopus subject areas

  • Pharmacology

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