Studies into the anticancer effects of selenomethionine against human colon cancer

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Abstract

Colorectal cancer is the third most frequent fatal malignant neoplasm in the United States and is expected to cause significant morbidity and mortality. The recent recall of cyclooxygenase-2 inhibitors from clinical trials highlights the need to develop other agents for cancer chemoprevention trials. Intervention strategies with selenium compounds represent a viable option to reduce colon cancer. Here we discuss epidemiologic studies and ongoing clinical trials with selenium. In addition, we discuss preclinical mechanistic studies that provide insights into the biochemical and molecular bases for the anticancer effects of selenomethionine.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume1059
DOIs
StatePublished - Jan 1 2005

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Keywords

  • Cancer chemoprevention
  • Colon cancer
  • ERK
  • Histone H3
  • Selenomethionine

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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