Studies of mixed liposomes with novel sorbyl functionalized head group lipids

Saliya N. Ratnayaka, El Hadj Elandaloussi, Bryan D. Korth, Robert B. Bates, Jeffrey Pyun, Henry K. Hall, S. Scott Saavedra

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Three novel polymerizable amphiphiles with a sorbyl-substituted head group were synthesized and systematically characterized. These amphiphiles are neutral in charge. None of these molecules forms vesicles by itself, presumably due to lack of amphiphilicity and/or extensive head group interaction. Therefore, mixed vesicles were formed with other fluid lipids such as DPenPC, eggPC, or DOPC. We investigated the properties of these mixtures in both vesicles and Langmuir films. The Langmuir isotherms show formation of monolayers by all three molecules. However, the isotherms for mixed monolayers suggest that two components are largely immiscible to the mixing lipid. Under polymerization conditions, mixed vesicles of these amphiphiles form oligomers, suggesting that in spite of a larger head group, they form mesophases.

Original languageEnglish (US)
Pages (from-to)809-817
Number of pages9
JournalChemistry and Physics of Lipids
Volume165
Issue number8
DOIs
StatePublished - Dec 1 2012

Keywords

  • Langmuir isotherms
  • Mixed liposomes
  • Polymerizable lipids
  • Sorbyl groups

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

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