Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs

Sarath N. Arseculeratne, A. A.Leslie Gunatilaka, Ralph G. Panabokke

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Seventy five medicinal plants of the traditional Ayurvedic pharmacopoeia of Sri Lanka have been screened chemically for alkaloids and pyrrolizidine alkaloids. Of these, Crotolaria juncea L. was found to contain pyrrolizidine alkaloids with biological effects consistent with pyrrolizidine alkaloid toxicity. Feeding trials in rats with three plants lacking pyrrolizidine alkaloids, namely Aegle marmelos (L.) Corr., Hemidesmus indicus (L.) Ait. F. and Terminalia chebula Retz. produced hepatic lesions which included central vein abnormalities while Terminalia chebula and Withania somnifera (L.) Dunal produced marked renal lesions.

Original languageEnglish (US)
Pages (from-to)323-335
Number of pages13
JournalJournal of Ethnopharmacology
Volume13
Issue number3
DOIs
StatePublished - Jul 1985
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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