Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid

K. H. Lee, Theodore G. Tong

Research output: Contribution to journalArticle

15 Scopus citations


Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.

Original languageEnglish (US)
Pages (from-to)773-774
Number of pages2
JournalJournal of pharmaceutical sciences
Issue number6
StatePublished - Jun 1969



  • Hydrocortisone, predisone effect—wound healing
  • Retinoic acid effect—drug‐retarded wound healing
  • Salicylic acid effect—wound healing
  • Wound healing—tensile strength

ASJC Scopus subject areas

  • Pharmaceutical Science

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