Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid

K. H. Lee; Theodore G. Tong

doi:10.1002/jps.2600580633

Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid

K. H. Lee, Theodore G. Tong

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.

Original language	English (US)
Pages (from-to)	773-774
Number of pages	2
Journal	Journal of pharmaceutical sciences
Volume	58
Issue number	6
DOIs	https://doi.org/10.1002/jps.2600580633
State	Published - Jun 1969
Externally published	Yes

Keywords

Hydrocortisone, predisone effect—wound healing
Retinoic acid effect—drug‐retarded wound healing
Salicylic acid effect—wound healing
Wound healing—tensile strength

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600580633

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title = "Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid",

abstract = "Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.",

keywords = "Hydrocortisone, predisone effect—wound healing, Retinoic acid effect—drug‐retarded wound healing, Salicylic acid effect—wound healing, Wound healing—tensile strength",

author = "Lee, {K. H.} and Tong, {Theodore G.}",

note = "Funding Information: Received December 6, 1968, from the Department of Pharmacy, Massachusetts ColIege of Pharmacy, Boston, MA 02115 Accepted for publication January 27,1969. Abstracted from a thesis submitted by Donald G. Floriddia to the Massachusetts College of Pharmacy, in partial fulfillment of the Master of Science degree requirements. This investigation was by a research grant from Chesebrough-Pond's, Inc., Clinton, CT * Present address: Purdue Frederick Co., Yonkers, NY 10701 t Present address: College of Pharmacy, Northeastern University Boston, MA 02115",

year = "1969",

month = jun,

doi = "10.1002/jps.2600580633",

language = "English (US)",

volume = "58",

pages = "773--774",

journal = "Journal of Pharmaceutical Sciences",

issn = "0022-3549",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

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T1 - Studies on the mechanism of action of salicylates vi

T2 - Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid

AU - Lee, K. H.

AU - Tong, Theodore G.

N1 - Funding Information: Received December 6, 1968, from the Department of Pharmacy, Massachusetts ColIege of Pharmacy, Boston, MA 02115 Accepted for publication January 27,1969. Abstracted from a thesis submitted by Donald G. Floriddia to the Massachusetts College of Pharmacy, in partial fulfillment of the Master of Science degree requirements. This investigation was by a research grant from Chesebrough-Pond's, Inc., Clinton, CT * Present address: Purdue Frederick Co., Yonkers, NY 10701 t Present address: College of Pharmacy, Northeastern University Boston, MA 02115

PY - 1969/6

Y1 - 1969/6

N2 - Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.

AB - Oral administration of sodium salicylate or prednisone and topical application of salicylic acid or hydrocortisone in NIB retards healing and the inhibitory action of either one of these drugs can be reversed by local application of retinoic acid. Topical application of retinol, retinyl esters, or retinoic acid alone also promotes skin wound healing in the rat.

KW - Hydrocortisone, predisone effect—wound healing

KW - Retinoic acid effect—drug‐retarded wound healing

KW - Salicylic acid effect—wound healing

KW - Wound healing—tensile strength

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IS - 6

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Studies on the mechanism of action of salicylates vi: Effect of topical application of retinoic acid on wound‐healing retardation action of salicylic acid

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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